GSE138233 Transcriptomic analysis of DOXO-Resistant cells compared to parental DOXO-Sensitive mda-mb-436 cell line

Contributors : Isabelle Sirois ; Adriana Aguilar-Mahecha ; Josiane Lafleur ; Emma Fowler ; Viet Vu ; Michelle Scriver ; Marguerite Buchanan ; Catherine Chabot ; Aparna Ramanathan ; Banujan Balachandran ; Stephanie Legare ; Ewa Przybytkowski ; Cathy Lan ; Urszula Krzemien ; Luca Cavallone ; Olga Aleynikova ; Cristiano Ferrario ; Marie-Christine Guilbert ; Naciba Benlimame ; Amine Saad ; Moulay Alaoui-Jamali ; Horace Uri Saragovi ; Sylvia Josephy ; Ciara O'Flanagan ; Stephen D Hursting ; Vincent R Richard ; Rene P Zahedi ; Christoph H Borchers ; Eric Bareke ; Sheida Nabavi ; Peter Tonellato ; Josee-Anne Roy ; Andre Robidoux ; Elizabeth A Marcus ; Catalin Mihalcioiu ; Jacek Majewski ; Mark BasikSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe major obstacle in successfully treating triple negative breast cancer (TNBC) is resistance to cytotoxic chemotherapy, the mainstay of treatment in this disease. Previous pre-clinical models of chemoresistance in TNBC have suffered from a lack of clinical relevance. Using a single high dose chemotherapy treatment, we developed a novel MDA-MB-436 cell-based model of chemoresistance characterized by a unique and complex morphological phenotype, which consists of polyploid giant cancer cells (PGCCs) giving rise to neuron-like mononuclear daughter cells filled with smaller but functional mitochondria and numerous lipid droplets. This resistant phenotype is associated with metabolic reprogrammi...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research