Economic evaluation of the introduction of 4CMenB (Bexsero ®) in the national vaccine schedule in Spain.
CONCLUSIONS: Given the current incidence of invasive meningococcal disease in Spain and the information available from 4CMenB, our model shows that routine vaccination is not cost-effective at the current price. Only with a vaccine price of 1.45 € for the 3+1 schedule or 3.37 € for the 2+1 schedule could it be recommended based on efficiency criteria. PMID: 31776044 [PubMed - as supplied by publisher]
New England Journal of Medicine,Volume 382, Issue 4, Page 309-317, January 2020.
New England Journal of Medicine,Volume 382, Issue 4, Page 318-327, January 2020.
Condition: Meningococcal Infections Intervention: Biological: Meningococcal Group ACYW135 Conjugate Vaccine Sponsor: Walvax Biotechnology Co., Ltd. Completed
Opisthotonos, extreme involuntary neck and back extension, is rarely seen in modern emergency departments. Vaccines have prevented the most common causes of this clinical presentation. Alternatively, otitis media is one of the most common pediatric infections and is characteristically non-invasive and harmless. In exceedingly rare cases, otitis media can develop complications and progress to invasive pneumococcal diseases including mastoiditis and meningitis. Streptococcus pneumoniae accounts for the majority of otitis media infections, however, since the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) a...
We present 3 cases of recurrent pneumococcal meningitis where detailed neuro-imaging revealed subtle anterior base of skull defects not detected on initial investigations.
Authors: Zintgraff J, Fossati S, Pereira CS, Veliz O, Regueira M, Moscoloni MA, Irazu L, Lara C, Napoli D, Argentina Spn Working Group Abstract Streptococcus pneumoniae is a major cause of severe invasive disease associated with high mortality and morbidity worldwide. To identify the serotypes most commonly associated with infection in adults in Argentina, 791 pneumococcal isolates from 56 hospitals belonging to 16 provinces and Buenos Aires city were serotyped. The isolates were submitted as part of a National Surveillance Program for invasive pneumococcal disease in adults, which started in 2013. Serotypes 3, 8, ...
Condition: Preventive Immunization; Meningitis Intervention: Biological: Menactra Sponsor: Brigham and Women's Hospital Not yet recruiting