Lyme disease in children: Data from the Canadian Paediatric Surveillance Program

ConclusionThis study of the clinical spectrum of LD in Canadian children underlines the need for preventive measures to protect children in Canada from emerging LD, and the need for health care provider awareness.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research

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Authors: Childress A, Hoo-Cardiel A, Lang P Abstract Introduction: Attention-deficit/hyperactivity disorder (ADHD) commonly occurs in children, adolescents, and adults. Although symptoms of ADHD often respond robustly to treatment with stimulants (amphetamine or methylphenidate), not all patients are appropriate candidates for treatment with these drugs. Guanfacine extended-release (GXR) is a non-stimulant alternative drug approved for the treatment of ADHD in the United States (U.S.), Canada, and Europe.Areas covered: The chemistry, pharmacokinetics, mechanism of action and dosage of GXR are presented. Efficacy an...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
In this study, we detected in Northern Africa two putatively novel Rickettsia species in soft tick species of the Ornithodoros erraticus complex: Ornithodoros occidentalis from Morocco, Ornithodoros erraticus from Algeria and Ornithodoros normandi from Tunisia. We characterized these two novel Rickettsia species on the basis of comparative DNA sequence analyses and phylogenetics of four genes (gltA, 16S rRNA, coxA and ompB). These Rickettsia, provisionally named ‘Candidatus Rickettsia africaseptentrionalis’ and ‘Candidatus Rickettsia mauretanica’, differed in nucleotide sequence from those of other ...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 23 January 2020Source: Molecular Phylogenetics and EvolutionAuthor(s): Deng-Feng Xie, Yan Yu, Jun Wen, Jiao Huang, Jun-Pei Chen, Juan Li, Song-Dong Zhou, Xing-Jin HeAbstractAllium L. is one of the largest monocotyledonous genera with an extensive distribution in the Northern Hemisphere. The fundamental phylogenies of Allium have been investigated using many morphological and molecular characters. However, the morphological characters may not agree with the molecular results in some Allium groups or sections (such as the Chinese Allium section Daghestanica), which may result in ambiguous s...
Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
In this study, we investigated the effect of 5-AIQ on sociability tests, self-grooming, marble burying, and locomotor activities in BTBR T+ Itpr3tf/J (BTBR) mice, which serve as an ASD animal model. We further investigated the possible molecular mechanism of 5-AIQ administration on CXCR4-, CXCR6-, IFN-γ-, IL-22-, NOS2-, STAT1-, T-bet-, and RORγT-producing CD3+ T cells isolated from the spleens of treated mice. We also explored its effects on mRNA expression in brain tissue. Our results showed that in BTBR mice, 5-AIQ treatment significantly prevented self-grooming and marble burying behaviors and enhanced socia...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Publication date: April 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 188Author(s): Vivian Meira Moia, Filipe Leal Portilho, Tatiana Almeida Pádua, Luana Barbosa Corrêa, Eduardo Ricci-Junior, Elaine Cruz Rosas, Luiciana Magalhaes Rebelo Alencar, Francisco Savio Mendes Sinfronio, Angelina Sampson, Surtaj Hussain Iram, Frank Alexis, Maria dasGraccedilasMuller de OliveiraHenriques, Ralph Santos-OliveiraAbstractLycopene is a carotenoid drug that has demonstrated several properties, including antioxidant and anti-inflammatory activity. The absorption in human body is very low (10–30 % only). In o...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Abstract The efficacy and safety of targeted treatment for elderly patients with rheumatoid arthritis (RA) was considered. Patients with RA who met the ACR/EULAR 2010 classification criteria and were treated consecutively for> 3 years, were recruited and classified into three age groups with 10-year increments from 65 years. Treatment protocol that aims to achieve clinical remission within 6 months was commonly adopted. The salient features are the rapid increase in dosages of conventional synthetic anti-rheumatic drugs (csDMARDs) and the administration of need-based concomitant biologic/targeted synthetic drug...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
Why might certain rheumatoid arthritis patients choose not to adhere to methotrexate therapy? Could certain factors predict non-adherence?Rheumatology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news
BCG vaccination is an important global health measure in countries with endemic tuberculosis but poses significant risks when administered to patients with Severe Combined Immune Deficiency (SCID) or genetic defects associated with Mendelian Susceptibility to Mycobacterial Diseases (MSMD). A study by Marciano et al. reported that BCG-osis occurred in over 50% of BCG-vaccinated patients with SCID. The impact of this infection on allogeneic hematopoietic stem cell transplant (HSCT) outcomes is unclear.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 529 Source Type: research
This study presented examples of base-calling DNA sequencing electropherograms routinely generated in a clinical diagnostic laboratory on DNA extracts of human blood specimens and ticks collected from human skin bites and from the environment. Since some of the tick samples tested were collected in Ireland, borrelial species or strains not known to exist in the United States were also detected by analysis of this 16S rRNA “core genome”. We recommend that hospital laboratories located in Lyme disease endemic areas begin to use a “core genome” sequencing test to routinely diagnose spir...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
AbstractPurpose of ReviewLyme disease is a tick-borne zoonosis transmitted through a bite of a tick carrying a spirochete belonging toBorrelia species. In the last 20  years, the reported incidence of Lyme disease is increased by three times in Europe. Clinically, the illness develops through a primary stage with a typical skin rash (erythema marginatum), then a secondary stage with possible neurologic or cardiac involvement. The last stage (chronic Lyme disease ) is mainly represented by arthritis or late neurological complications but nowadays is rarely seen due to precocious antibiotic use.Recent FindingsThe diagno...
Source: Current Infectious Disease Reports - Category: Infectious Diseases Source Type: research
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