ROCK2 as a novel target for diabetic cardiomyopathy

We read with interest your letter to the editor expressing concern about using ROCK2 inhibition for diabetic cardiomyopathy (DCM) management, as it may promote tumor metastasis and disturb some physiological functions. However, the effect of ROCK2 on metastasis seems to be tumor and context specific. In fact, numerous studies reported a metastasis-promoting role for ROCK2 in tumors like gastric cancer [1] hepatocellular carcinoma [2] and osteosarcoma [3], and that ROCK2 inhibition produced beneficial effects.

Source: International Journal of Cardiology - November 30, 2019 Category: Cardiology Authors: Hesham Soliman, Vongai Nyamandi, Leif Hove-Madsen, Kathleen M. MacLeod Source Type: research