Resveratrol Reserved Hypoxia-Ischemia Induced Childhood Hippocampal Dysfunction and Neurogenesis via Improving Mitochondrial Dynamics

Publication date: Available online 29 November 2019Source: Neuroscience ResearchAuthor(s): Hong Li, Xiao Li, Zhizhen Liu, Shirun Wu, Jinwei Guo, Ruiling Shi, Yuqing Sun, Yufei Wang, Huaiqing YinAbstractEarly life stress usually causes the abnormal brain development and results in the onset of cognitive and emotional disorders in later childhood. Neonatal hypoxic ischemia (HI) causes dramatic brain damage in early life and resulted in serious impairment to brain development. Hippocampal neurogenesis, as one of the key structural plasticity to mediate animal behaviors, can be impact by neonatal HI until child stage. In our study, we identified the natural product resveratrol (RES) as the potential alternative therapy to improve brain functions of childhood mice after underwent neonatal HI. Treatment of RES improved the spatial learning and memory in morris water maze and increased the recognize ability in objective recognition task. Moreover, RES also attenuate the depressive and anxiety like mood in child mice after experiencing neonatal HI. Brain morphological study showed RES promote the proliferation of neural stem cells and increase the neuronal differentiation in hippocampal dentate gyrus (DG) region. Our in vitro study in C17.2 neural stem cell line demonstrated RES could prevent the mitochondrial fragmentation induced by hypoxia. Moreover, same effect was also observed in primary cultural neurons. To summarize, RES could prevent the cognitive deficit and depressive/anxi...
Source: Neuroscience Research - Category: Neuroscience Source Type: research

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Publication date: Available online 25 January 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): H. Saghafi, P. Benington, A. AyoubAbstractThe aim of this study was to compare the impact that the orthodontics-first approach and the surgery-first approach have on quality of life, anxiety, and depression in patients treated for dentofacial deformities. Data were collected on 32 patients (aged 17–47 years) who were all treated at a single multidisciplinary orthognathic clinic. They completed a 22-item Orthognathic Quality of Life Questionnaire (OQLQ), a seven-item Generalised Anxiety Disorder (GAD-7...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
In this study, we examined the clinical and psychosocial characteristics of youth at familial and clinical high risk (HR) for BD, and compared these characteristics to those of youth with BD I and II. Both groups were recruited based on current, active mood symptoms from separate randomized trials of family therapy. A total of 127 HR youth were evaluated: 52 (40.9%) were diagnosed with BD-NOS and 75 (59.1%) were diagnosed with MDD. Compared to adolescents with BD I and II (n=145), HR youth had higher rates of anxiety disorders, and comparable rates of attention-deficit/hyperactivity disorder and oppositional defiant disord...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
ConclusionsFurther longitudinal research is needed to clarify the association between paternal mental health disorders other than depression, and adolescent anxiety or depression. Mechanisms in this relationship should also be further explored, and could be informed by existing models on younger children.
Source: Journal of Adolescence - Category: Child Development Source Type: research
“I have self-doubt. I have insecurity. I have fear of failure… We all have self-doubt. You don’t deny it, but you also don’t capitulate to it. You embrace it.” – Kobe Bryant Everyone, no matter who they are, inevitably experiences self-doubt. Reading through the biographies and autobiographies of some of the most accomplished, celebrated, famous, talented and intelligent people reveals that each one of them has had their moments of personal doubt. Not only did they wonder if they had what it takes, they worried whether they could persevere despite opposition and setbacks, without suppor...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Motivation and Inspiration Self-Help Confidence Self-Doubt Source Type: blogs
Depression and anxiety are prevalent in pediatric palliative care and a source of significant distress for patients and parents. Despite increasing recognition of the need to address these symptoms, many palliative care providers have limited psychiatric training and limited access to psychology services. This session includes pediatric palliative care providers trained in adult and child psychiatry and psychology to increase attendees' skills to address these symptoms in children, teenagers, and young adults cared for by pediatric palliative care teams.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
Congenital anomalies are the leading cause of infant death in the United States. Nearly 25% or parents who experience perinatal loss develop long-term adverse psychosocial outcomes resulting from intense grief, such as depression, anxiety, substance abuse, posttraumatic stress disorder, and suicidal ideation. The majority of perinatal loss research has focused on miscarriage and stillbirth, necessitating investigation into the impact of lethal congenital anomalies.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
This article details more of the report’s findings. Mental Health at Work: How It Affected My First Job: Young employees are the most vulnerable for experiencing poor mental health on the job, according to research. For some, making the transition from school to a first job can be particularly daunting. This article highlights two young employees and their struggles with mental health issues. Getting Mental Health Care Can Be Hard Enough. Then Comes Paying for It: Have you ever had to fight an insurance company to get mental health coverage? Joe and Enita Dugan know this battle well, as their son has long struggled w...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: ADHD and ADD Anxiety and Panic Children and Teens Depression Disorders General LifeHelper Mental Health and Wellness Professional Psychology Psychology Around the Net Self-Help Stress Students first job Immigrants Lonelines Source Type: blogs
It is intuitive to expect youth with IBD will have higher rates of depression and anxiety than their otherwise healthy peers, and most research bears this notion. However, existing literature of emotional distress has not consistently addressed the differentiation between general depression and anxiety and normative emotional experiences of IBD. Assessment measures often used for youth with IBD align with the DSM criteria; based on symptoms, without considering etiology or context (e.g., chronic disease).
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Quality of Life/Psychosocial Care Source Type: research
While restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the preferred surgical approach in patients with medically refractory ulcerative colitis (UC) or UC-related dysplasia, a significant proportion of patients develop pouchitis and/or report decreased health related quality of life (HRQOL) at some point after IPAA. We designed this study to 1) evaluate the association between recently reported pouchitis and specific Patient-Reported Outcome Measurement Information System (PROMIS) domains (anxiety, depression, fatigue, pain interference, sleep disturbance, and social role satisfaction) and HRQOL as a...
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Quality of Life/Psychosocial Care Source Type: research
Both depression and anxiety are comorbidities of inflammatory bowel disease (IBD). Though previous studies have proposed a relationship between depression, anxiety and IBD, causality and directionality are unknown. We used a novel computerized adaptive testing technology to screen IBD patients for depression and anxiety and  compared the screening results to disease activity.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Quality of Life/Psychosocial Care Source Type: research
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