Developing vaccines against epidemic-prone emerging infectious diseases.
Developing vaccines against epidemic-prone emerging infectious diseases. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Nov 27;: Authors: Bernasconi V, Kristiansen PA, Whelan M, Román RG, Bettis A, Yimer SA, Gurry C, Andersen SR, Yeskey D, Mandi H, Kumar A, Holst J, Clark C, Cramer JP, Røttingen JA, Hattchet R, Saville M, Norheim G Abstract Today's world is characterized by increasing population density, human mobility, urbanization, and climate and ecological change. This global dynamic has various effects, including the increased appearance of emerging infectious diseases (EIDs), which pose a growing threat to global health security.Outbreaks of EIDs, like the 2013-2016 Ebola outbreak in West Africa or the current Ebola outbreak in Democratic Republic of the Congo (DRC), have not only put populations in low- and middle-income countries (LMIC) at risk in terms of morbidity and mortality, but they also have had a significant impact on economic growth in affected regions and beyond.The Coalition for Epidemic Preparedness Innovation (CEPI) is an innovative global partnership between public, private, philanthropic, and civil society organizations that was launched as the result of a consensus that a coordinated, international, and intergovernmental plan was needed to develop and deploy new vaccines to prevent future epidemics.CEPI is focusing on supporting candidate vaccines against the World Health Organization (WHO) Blue...
This study also shortlists the essential genes of N. gonorrhoeae that could be used to target Neisseria. We identified a molecule/drug which can be used to target essential protein DapD (succinyltransferase).
In this study, we designed a tandem sequence of CpG ODN synthesized in plasmid pcDNA 3.1, and an inactivated Vibrio anguillarum vaccine developed in our previous work was chosen for determining the efficiency of the CpG-riched plasmids (pCpG) as an adjuvant. Results showed that pCpG we designed can offer higher immunoprotection with the vaccine. Interestingly, even below the minimum immune dosage of the vaccine, a high RPS of 84% was observed once the vaccine was administrated with the pCpG. Serum specific antibody titer, superoxide dismutase and total protein were enhanced and some immune genes related to both innate and ...
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9NJ05706D, PaperAna Lu ísa Costa, Ana C. Gomes, Andre D Lopes, Jose P Da Silva, Martyn Pillinger, Isabel S. Goncalves, Joao Sergio Seixas de Melo The ability of cucurbit[n]urils (CB[n]) to decolourise aqueous solutions of the azo dye Congo red (CR) was described more than a century ago alongside the first synthesis of CB[n]. No... The content of this RSS Feed (c) The Royal Society of Chemistry
[News24Wire] The Gauteng Department of Health has confirmed that 10 babies died at Tembisa Hospital's neonatal unit between November and December last year, due to a Carbapenem-resistant Enterobacteriaceae (CRE) outbreak.
The outbreak started in Wuhan, China, andaccording to De Volkskrant (in Dutch) has spread to Shenzhen and to Beijing.This new virus is causing SARS like symptoms, but is not thought to be SARS itself. It seems to have no name yet.Here are some information resources about it:UK governmentPublic Health England.EUEuropean Centre for Disease Prevention and Control.WHO WHOnews release WHOemergency preparedness responseTheWHO Thailand page has links to information.Nature' sNews roundup on 15th January has a summary, and there was anews item on 8th January.For instances of the virus and latest...
BACKGROUND: Opiate misuse has reached epidemic levels. Prevention efforts depend on distinguishing opiate users from abusers. The current study compared opioid users who died by natural cases, accidents, and suicide using psychological autopsy methods. Gro...
GIDEON what’s new summary: January 19 to January 20, 2020 Infectious Diseases – Outbreaks (4 updates) 4 DiseasesMap Infectious Diseases – Diseases (79 updates) 36 Diseases43 Country notesMap The post Update: January 20, 2020 appeared first on GIDEON - Global Infectious Diseases and Epidemiology Online Network.
[Daily News] THE Ministry of Health, Community Development, Gender, Elderly and Children is mulling over setting up guidelines for street food vendors with the view of controlling outbreak of diseases.
An outbreak of a new coronavirus in China has spread to more cities, Chinese authorities said on Monday, as the number of patients tripled and a third person died, stoking concerns about containment of the illness.
Chinese authorities and the World Health Organization (WHO) say a new strain of coronavirus is behind the outbreak of pneumonia in the central city of Wuhan, which has erupted just ahead of the Lunar New Year, the country's biggest festival.
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