Vaccine-preventable meningitis in French children with incorrect vaccination status from 2011 to 2013.

The objective of this study was to determine the number of cases of pediatric meningitis or purpura fulminans associated with an incorrect vaccination status from 2011 to 2013 in France. A total of 48 children with vaccine-preventable meningitis or purpura fulminans, including three deaths, had an incorrect vaccination status: 26 cases were due to Neisseria meningitidis group C (54.2%), 19 to Streptococcus pneumoniae (39.6%), and three to Haemophilus influenzae type b (6.3%). The majority of patients (n=35, 72.9%) had received no injection of the vaccine concerned. Over a 3-year period, 48 cases of bacterial meningitis or purpura fulminans in children could have been avoided if the French immunization schedule had been followed. PMID: 31776077 [PubMed - as supplied by publisher]
Source: Archives de Pediatrie - Category: Pediatrics Authors: Tags: Arch Pediatr Source Type: research

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Authors: İşeri Nepesov M, Dinleyici M, Kılıç Ö, Ceyhan M, Gürler N, Dinleyici EÇ Abstract Streptococcus pneumoniae is a major cause of bacterial meningitis in children. It can progress and carries a serious risk of mortality and morbidity despite effective treatment. Cochlear implantation is a fairly successful procedure for restoring hearing in cases of sensorineural hearing loss. Moreover, patients with cochlear implants are at increased risk of contracting pneumococcal meningitis compared to the general population. The development of meningitis is associated with pathogens in the midd...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Publication date: Available online 2 September 2019Source: Journal of Microbiological MethodsAuthor(s): Ali Pormohammad, Taher Azimi, Seyedeh Marzieh Jabbari Shiadeh, Ghazaleh Talebi, Ali Hashemi, Elham Abbasi, Fatemeh FallahAbstractThe present study aimed to design a sensitive, specific and rapid multiplex real-time PCR for detection of the common causative agents of meningitis. Also, we aimed to report valuable genotyping data from Iran for establishing future vaccination and prevention strategies for the meningitis. From July 2015 to January 2018, 325 suspected cases of meningitis were enrolled in the current study. Uni...
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
Abstract Haemophilus influenzae type b (Hib) causes various invasive infections, such as meningitis, septic arthritis, and pneumonia, especially in children under 5 years of age. Despite Hib vaccines protect Hib infection, seroepidemiological surveys of Hib infections have not been conducted systematically in Japan thus far. We analyzed 1,338 serum samples from 0-5-year-old children that were provided by the National Serum Reference Bank of the National Institute of Infectious Diseases (Tokyo, Japan). Serum levels of the anti-polyribosylribitol phosphate (PRP) IgG antibody against the Hib were determined using an ...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research
Background: Central nervous system infections are an important cause of childhood morbidity and mortality in high HIV-prevalence settings of Africa. We evaluated the epidemiology of pediatric meningitis in Botswana during the rollout of antiretroviral therapy, pneumococcal conjugate vaccine and Haemophilus influenzae type B (HiB) vaccine. Methods: We performed a cross-sectional study of children (
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Publication date: June 2019Source: The Lancet Global Health, Volume 7, Issue 6Author(s): Brian Wahl, Apoorva Sharan, Maria Deloria Knoll, Rajesh Kumar, Li Liu, Yue Chu, David A McAllister, Harish Nair, Harry Campbell, Igor Rudan, Usha Ram, Molly Sauer, Anita Shet, Robert Black, Mathuram Santosham, Katherine L O'Brien, Narendra K AroraSummaryBackgroundIndia accounts for a disproportionate burden of global childhood illnesses. To inform policies and measure progress towards achieving child health targets, we estimated the annual national and state-specific childhood mortality and morbidity attributable to Streptococcus pneum...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Vega Masignani1, Mariagrazia Pizza1 and E. Richard Moxon2* 1GSK Vaccines, Siena, Italy 2Department of Pediatrics, Oxford University, Oxford, United Kingdom The discovery of vaccine antigens through whole genome sequencing (WGS) contrasts with the classical hypothesis-driven laboratory-based analysis of microbes to identify components to elicit protective immunity. This radical change in scientific direction and action in vaccine research is captured in the term reverse vaccinology. The complete genome sequence of an isolate of Neisseria meningitidis serogroup B (MenB) was systematically analyzed to identify prot...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsAny difference in price between PHiD-CV and PCV13 is expected to be the key driver of vaccine choice for preventing childhood pneumococcal disease in Turkey. At price parity, PHiD-CV use is likely to be a dominant strategy over the use of PCV13.
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
Conclusions: This study provides data that allow recommending authorities to consider the use of a sequential hexavalent-pentavalent-hexavalent primary vaccination series followed by a pentavalent booster in coadministration with other common childhood vaccines.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
CONCLUSIONS: H. influenzae b conjugate vaccine reduced the number of cases of H. influenzae b meningitis and probable meningitis within the first two years of its introduction. The impact against meningitis was higher than the vaccination rate, indicating indirect effects of the vaccine. India has recently scaled up the use of Hib conjugate vaccine throughout the country which should substantially reduce childhood meningitis rates further in the country. PMID: 30772069 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
CONCLUSION: This large study shows that the proportion of children with delayed vaccination in France was globally high and substantial for Men-C and the first MMR vaccination. Risk of a delayed second and third dose was increased with a delayed first dose, which may reflect vaccine hesitancy. PMID: 30638762 [PubMed - as supplied by publisher]
Source: Archives de Pediatrie - Category: Pediatrics Authors: Tags: Arch Pediatr Source Type: research
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