Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D

AbstractHuman adenovirus (HAdV) commonly causes infections of respiratory, gastrointestinal, genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are mild and self ‐limited, specific viruses within human adenovirus species D (HAdV‐D) are associated with epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular surface infection, which can lead to chronic and/or recurrent, visually disabling keratitis. In this review, we discuss the links b etween adenovirus ontogeny, genomics, immune responses, and corneal pathogenesis, for those viruses that cause EKC.
Source: FEBS Letters - Category: Biochemistry Authors: Tags: REVIEW Source Type: research