Meth Use Linked to Deadly Fungal InfectionMeth Use Linked to Deadly Fungal Infection

Methamphetamine use has been linked to cryptococcosis, a deadly lung infection, new research suggests. Medscape Medical News
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news

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AbstractPurpose of ReviewAcquired resistance among fungal strains is a growing concern. The reasons for the emergence of this phenomenon, with great clinical implications, are only partially explained and related to the frequent use of fluconazole prophylaxis or therapeutic regimens in medical practice, and evidence of environmental origin of resistance is warranted.Recent FindingsSoil exposed to azole fungicides may select acquired resistant fungal strains and improve the proliferation and maintenance of phenotypes in this environment. So far, the greatest focus on cross-resistance in relation to azoles is with genusAsper...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Cryptococcus species are associated with invasive fungal infections in immunosuppressed individuals. The clinical significance of low-titer cryptococcal antigen (CrAg) by lateral flow assay is frequently uncertain. We investigated the correlation of low CrAg titers with disease in an immunocompromised patient population. Patients with first-time positive CrAg results with low serum titers (≤1:10) at two medical centers (Los Angeles, CA) from April 2014 to July 2018 were included. Age-matched controls with high (≥1:20) and negative titers were selected. We extracted medical records for pertinent clinical, radiologic, ...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Immunoassays Source Type: research
oza O Abstract Amphotericin B (AmB) is the antifungal with the strongest fungicidal activity, but its use has several limitations, mainly associated to its toxicity. Although some lipidic and liposomal formulations that present reduced toxicity are available, their price limits their application in developing countries. Flucytosine (FC) has shown synergistic effect with AmB for treatment of some fungal infections, such as cryptococcosis, but again, its price is a limitation for its use in many regions. In the present work, we aimed to identify new drugs that having a minor effect on C. neoformans, reduced its grow...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
We described a case of an apparently immunocompetent 66-years old man admitted to hospital with a one-month history of cough, fever and vertigo. During hospitalization, thorax imaging was suggestive of lung metastasis, therefore, he went through several investigations. During hospitalization, he developed neurological symptoms and subsequently underwent a lumbar puncture. Cerebrospinal fluid (CSF) culture was positive for Cryptococcus spp. isolated on Sabouraud's dextrose agar and bird seed agar. In addition, the direct microscopy examination was positive for the India ink test, as well as with the latex agglutination test...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
AbstractPurpose of ReviewCryptococcal meningitis is one of the most seriously opportunistic infections in people living with HIV. We evaluated clinical and laboratorial features (minimum inhibitory concentrations for fluconazole, initial fungal burden in cerebrospinal fluid) and risk factors associated with in-hospital mortality.Recent FindingsThere is no good evidence for the use of minimum inhibitory concentrations for fluconazole in routine practice for the management of cryptococcosis patients. Counting yeast cells at cerebrospinal fluid can predict positive culture by not death.SummaryData from 46 cryptococcal meningi...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Publication date: Available online 17 January 2020Source: European Journal of RadiologyAuthor(s): Animesh Ray, Ankit Mittal, Surabhi VyasAbstractPurposeThe CT Halo sign or Halo sign (HS) refers to ground-glass opacity surrounding a nodule or mass in the lung parenchyma. We conducted a systematic review to find the etiological associations of HS. We also evaluated the diagnostic performances of HS for invasive fungal infections (IFI) in immunosuppressed patients.MethodThe systematic review was conducted as per PRISMA guidelines. We searched the PubMed and EMBASE database till June 2018 without any restrictions. Only case re...
Source: European Journal of Radiology - Category: Radiology Source Type: research
We investigated the characteristics and associated factors of invasive fungal disease in patients with type  2 diabetes mellitus from Southern China for the first time. We found thatCandida albicans,Cryptococcus neoformans andAspergillus fumigatus were the leading agents. Prolonged hyperglycemia results in unfavorable outcomes. Correction of anemia and hypoalbuminemia might improve prognosis. AbstractAims/IntroductionA retrospective study was carried out to investigate the clinical characteristics and associated factors for invasive fungal disease in patients with type  2 diabetes mellitus.Materials and MethodsDe...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Original Article Source Type: research
Authors: Sindhu D, Jorwal P, Gupta N, Xess I, Singh G, Soneja M, Nischal N, Sethi P, Ray A, Biswas A, Wig N Abstract The aim of the study was to determine the clinical spectrum and outcome of invasive fungal infections (IFIs) in hospitalized patients. A prospective study was conducted in a teaching hospital in North India between December 2016 and December 2018. Patients diagnosed with IFIs were enrolled. Their clinical and laboratory parameters were recorded using a pre-defined clinical report form. They were followed up till discharge or death and a 60-day outcome was recorded. A total of 110 IFI cases were ident...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Conclusions: Given the significant risk of Cryptococcus species for susceptible humans, mainly HIV-infected patients, it seems quite necessary to adopt concrete preventive strategies to pinpoint the environmental habitats of this yeast.
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Publication date: Available online 6 December 2019Source: Wilderness &Environmental MedicineAuthor(s): James H. DiazCryptococcus neoformans, a soil-dwelling fungus found worldwide, can cause cryptococcosis, an opportunistic fungal infection of the lungs and central nervous system. One former member of the C neoformans complex, Cryptococcus gattii, has caused meningitis in immunosuppressed and immunocompetent persons in endemic regions in Africa and Asia. Between 1999 and 2004, C gattii caused outbreaks of human cryptococcosis in unexpected, nonendemic, nontropical regions on Vancouver Island, Canada, and throughout the...
Source: Wilderness and Environmental Medicine - Category: Environmental Health Source Type: research
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