Genetic polymorphisms in antioxidant enzymes modulate the susceptibility of idiosyncratic antituberculous drug ‐induced liver injury and treatment outcomes in patients with tuberculosis

ConclusionsGenetic polymorphisms ofNOS2 andMAFK are associated with ATDILI susceptibility in Chinese patients with tuberculosis. The variants inNOS2 andMAFK affect treatment outcomes of tuberculosis patients. Further studies are needed to better understand the molecular mechanisms of ATDILI susceptibility via regulation of the expression of ATDILI ‐susceptibility genes and proteins.

Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 18, 2019 Category: Drugs & Pharmacology Authors: Qin Sun, Wei Sha, Hai ‐peng Liu, Peng Wang, Zhi‐bin Liu, Wen‐wen Sun, He‐ping Xiao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research