Hormonal therapy (hCG and rhFSH) for infertile men with adult-onset idiopathic hypogonadotropic hypogonadism.

This study was conducted to examine the efficacy and safety of a combination of human chorionic gonadotropin (hCG) and recombinant human follicle-stimulating hormone (rhFSH) for inducing spermatogenesis in men with adult-onset IMHH. Seven men (34-45 years of age) with azoospermia and/or sexual dysfunction, with a low serum testosterone concentration, and apulsatile secretion of luteinizing hormone, were referred to our hospital for infertility. All had normal secondary sexual characteristics. Thorough endocrinologic examination and magnetic resonance imaging revealed no identifiable cause of hypogonadotropic hypogonadism. Adult-onset IMHH was diagnosed in all cases and treatment was started with 150 IU rhFSH and 5,000 IU hCG, both administered two times per week. Spermatogenesis was restored in five of the seven patients. During treatment one patient achieved spontaneous pregnancy with his wife, and spermatozoa recovered from the other four patients were frozen for future use in intracytoplasmic sperm injection. PMID: 25518839 [PubMed - as supplied by publisher]
Source: Systems Biology in Reproductive Medicine - Category: Reproduction Medicine Authors: Tags: Syst Biol Reprod Med Source Type: research

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In conclusion, this study found that patients with FES had abnormal functional connectivity in the amygdala subregions, and the altered rsFC was associated with positive symptoms. The present findings demonstrate the disruptive rsFC patterns of amygdala subregional-sensorimotor networks in FES and may provide new insights into the neuronal pathophysiology of FES.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
This study aims at examining the correlation between the pattern of brain atrophy of MCI patients and performance on financial abilities. Forty-four MCI patients and thirty-seven healthy controls underwent structural magnetic resonance imaging, and assessment of financial abilities by means of the Numerical Activities of Daily Living Financial battery (NADL-F). As compared to healthy controls, MCI patients showed impaired performance in three out of the seven domains assessed by NADL-F: Item purchase, percentage, and financial concepts. The patients’ performance in the NADL-F correlated with memory, language, visuo-s...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): B. Choi, H. Jung, B. Yu, H. Choi, J. Lee, D. Kim
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Researchers at the University of Texas Dallas (UTD) are playing with alchemy by transforming a virus into an organic radical contrast agent (ORCA), an alternative to gadolinium-based contrast agents to be used in magnetic resonance imaging (MRI) procedures. ORCA molecules had been previously considered too dim for scanning and were easily eradicated by vitamin C in the body. UTD researchers found that by connecting the molecules to a  tobacco mosaic virus, a virus that attacks plant cells and disrupts cell activity, they were able to eliminate those issues and make the ORCA an effective agent. Once the ORCA ...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Infants born at 23 to 27 weeks of pregnancy are most vulnerable.
Source: AJN - Category: Nursing Tags: In the News Source Type: research
Publication date: Available online 19 February 2020Source: The LancetAuthor(s): Håvard Ove Skjerven, Eva Maria Rehbinder, Riyas Vettukattil, Marissa LeBlanc, Berit Granum, Guttorm Haugen, Gunilla Hedlin, Linn Landrø, Benjamin J Marsland, Knut Rudi, Kathrine Dønvold Sjøborg, Cilla Söderhäll, Anne Cathrine Staff, Kai-Håkon Carlsen, Anna Asarnoj, Karen Eline Stensby Bains, Oda C Lødrup Carlsen, Kim M Advocaat Endre, Peder Annæus Granlund, Johanne Uthus HermansenSummaryBackgroundSkin emollients applied during early infancy could prevent atopic dermatitis, and early comple...
Source: The Lancet - Category: General Medicine Source Type: research
In this long ‐term follow‐up of women with GDM, we found that 2‐hour glucose during OGTT at pregnancy predicted β‐cell function (as measured by ODI) 22 years post‐partum. Results of 2‐hour glucose during OGTT at pregnancy is a more useful indicator of long‐term metabolic risk. Most of the cases wh ich later converted to type 2 diabetes occurred within the first 15 years postpartum. AbstractAims/IntroductionWomen with gestational diabetes mellitus are at increased risk for type  2 diabetes. We characterized the association between maternal glycemia during pregnancy with long‐term outcomes.Methods a...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Original Article Source Type: research
ConclusionsThere is no clear evidence that the use of drugs during pregnancy and during the first year of life is associated with HSPM. Further well-designed prospective studies are needed.Clinical relevanceDetermining the etiological factors related to the development of HSPM would help to establish preventive protocols in patients at potential risk. As HSPM is predictive of molar incisor hypomineralisation (MIH), the application of preventive protocols would avoid complications in both the primary and permanent dentition.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
In a first of its kind case, a baby was born to a mother left infertile from cancer through IVM and egg freezing.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
[UNFPA in WCA] Bamako, February 20, 2020, On Thursday, February 20, the Regional Office of the United Nations Population Fund  (UNFPA) for West and Central Africa (WCARO) is organizing a session on "Demography, Peace and Security" as part of the 20th edition of the Bamako Forum "Africa on the horizon 2040: between memories and futures" which is held from February 20 to 22, 2020 in Bamako, Mali under the High Patronage of the President of  the Republic of Mali, His Excellency Ibrahim Boubacar Keita.
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
More News: Azoospermia | Biology | Endocrinology | Hormonal Therapy | Hormones | Hospitals | ICSI (Intracytoplasmic Sperm Injection) | Infertility | Low Testosterone | MRI Scan | Pregnancy | Reproduction Medicine | Sexual Dysfunction | Study