Bifurcation analysis of bistable and oscillatory dynamics in biological networks using the root-locus method

This study demonstrates the applicability of the root-locus-based bifurcation analysis method for studying the complex dynamics of such models. The effectiveness of the bifurcation analysis in determining the exact parameter regions in each of which the system shows a certain dynamical behaviour, such as bistability, oscillation, and asymptotically equilibrium dynamics is shown by considering two mostly studied gene regulatory networks, namely Gardner's genetic toggle switch and p53 gene network possessing two-phase (mono-stable/oscillation) dynamics.

Source: IET Systems Biology - November 29, 2019 Category: Biology Source Type: research