Embryonal rhabdomyosarcoma of the urachal ligament presenting as small bowel obstruction: Case report and review of the literature

Publication date: Available online 28 November 2019Source: Journal of Pediatric Surgery Case ReportsAuthor(s): Imad Aljabban, Christa GrantAbstractPediatric soft tissue sarcomas comprise a small proportion of pediatric solid malignancies and may arise in numerous anatomic locations such as the head and neck, trunk, extremities, and the genitourinary tract. Here, we present a case of rhabdomyosarcoma (RMS) arising from an unusual location, the urachus. The 3-year-old patient initially presented with signs of small bowel obstruction. On diagnostic laparoscopy, an infraumbilical mass was discovered and removed by laparotomy. Analysis of the specimen confirmed embryonal RMS (ERMS). The patient was treated with a regimen of postoperative chemotherapy and radiation therapy. Although rare, prompt diagnostic evaluation and treatment of RMS may improve the long-term morbidity and mortality of these patients.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research

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AbstractBackgroundPrevious studies have identified that patients withEGFR mutations tend to have better responses to targeted therapy, as well as chemotherapy; however, the effect of genetic alterations in terms of radiotherapy (RT) ‐related outcomes has not been fully assessed. We studied the impact of common non‐small cell lung cancer (NSCLC) genetic alterations (EGFR,ALK andKRAS) in relation to objective response rate (ORR) to RT in patients with brain metastases.MethodsFrom 2009 –2015, 153 patients with an available genotyping status were treated with whole‐brain irradiation (WBI) before receiving systemic ...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
L-GILZ binds and inhibits nuclear factor κB nuclear translocation in undifferentiated thyroid cancer cells. J Chemother. 2020 Feb 18;:1-5 Authors: Marchetti MC, Cannarile L, Ronchetti S, Delfino DV, Riccardi C, Ayroldi E Abstract Proto-oncogene mutations and abnormal activation of mitogen-activated protein kinase (MAPK) signalling are recurrently found in thyroid cancers. Some thyroid neoplasms respond to drugs that inhibit MAPK pathway activation. Previously, we showed that pharmacological inhibition of MAPK in thyroid cancer cells inhibits cell proliferation and upregulates L-GILZ (long glucoco...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
Authors: Maruta M, Miyoshi T, Matsuo N, Yamashina T, Irie K, Tsuruta M, Tsukada H, Tsuruyama M, Nagano M, Hiraki Y Abstract We administered FOLFOX (oxaliplatin (L-OHP) plus infusional 5-fluorouracil (5-FU) and leucovorin) to an hemodialysis (HD) patient with advanced gastric cancer (AGC), and investigated pharmacokinetics (PKs) and dialyzability of L-OHP. The patient was a 54-year-old Japanese man with a diagnosis of inoperable AGC. FOLFOX was instituted 3 h prior to the start of a 4 h HD period with the L-OHP and 5-FU doses reduced by 50% for the first cycle, and 30% reduced dose was administered for...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
Abstract The purpose of the present study was to evaluate the clinical profiles and treatment outcomes of patients with lung cancer admitted to the Medical Psychiatric Unit (MPU), which is built for patients with physical and severe psychiatric disorders. All medical records of patients with lung cancer admitted to the MPU of Tachikawa hospital were reviewed. The clinical outcomes of these patients were retrospectively evaluated between January 2010 and December 2016. A total of 24 patients in the MPU were histologically or cytologically diagnosed with primary lung cancer. Of these, 20 patients had schizophrenia, ...
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: Mol Clin Oncol Source Type: research
Authors: Zhou N, Hofstetter WL Abstract INTRODUCTION: Esophageal cancer is a deadly disease with high mortality. Treatment with chemotherapy, radiation, and surgery continues to leave many patients with disease progression and recurrence. Novel treatments are needed for this patient population. The development of molecular markers are important for identifying therapeutic targets, as well as prognosis.Areas covered:This review evaluates three molecular markers in esophageal cancer: HER2, PD-L1, and MSI. The fundamentals of these markers, diagnosis, and rates of occurrence in esophageal cancer are explored. The prog...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
Authors: Feldman T, Grossman-Haham I, Elkis Y, Vilela P, Moskovits N, Barshack I, Salame TM, Fass D, Ilani T Abstract Extracellular matrix (ECM) plays an important role in tumor development and dissemination, but few points of therapeutic intervention targeting ECM of the tumor microenvironment have been exploited to date. Recent observations suggest that the enzymatic introduction of disulfide bond cross-links into the ECM may be modulated to affect cancer progression. Specifically, the disulfide bond-forming activity of the enzyme Quiescin sulfhydryl oxidase 1 (QSOX1) is required by fibroblasts to assemble ECM co...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Montaudié H, Viotti J, Combemale P, Dutriaux C, Dupin N, Robert C, Mortier L, Kaphan R, Duval-Modeste AB, Dalle S, De Quatrebarbes J, Stefan A, Brunet-Possenti F, Kogay M, Picard-Gauci A, Poissonnet G, Peyrade F Abstract There is no standard of care for unresectable cutaneous squamous cell carcinoma (cSCC). Chemotherapy, alone or combined with radiotherapy, is commonly used mostly as palliative treatment; moreover, its poor safety profile limits its use most of the time, especially in elderly patients. Thus, alternative options are needed. Targeted molecular inhibitors, such as the epidermal growth ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Publication date: Available online 19 February 2020Source: Surgery (Oxford)Author(s): Christopher Limb, Timothy RockallAbstractLaparoscopic surgery is currently established as the primary modality for many procedures. In has been associated with a number of benefits over traditional open surgery, including reduced pain, shorter hospital stay and quicker return to work. Despite this, significant operative challenges and the potential for life-threatening complications exist. Surgeons must understand the specialist equipment that is required, along with how to troubleshoot common issues. Furthermore, an appreciation of the d...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
This article discusses factors to consider when choosing suture material, techniques for closure of a wound, and knots used to ligate a structure. With use of minimally invasive techniques now widespread, the article also discusses laparoscopic methods for performing such tasks.
Source: Surgery (Oxford) - Category: Surgery Source Type: research
This article outlines the biophysics of electrosurgery and tissue energy sources, including the basic concepts of both modalities. It explores the biophysics of electrodiathermy, including current density, waveforms and electrosurgical circuits. The principles of monopolar and bipolar diathermy are described with reference to the safety issues pertinent to implantable cardiac devices and other implants. Safe application of electrodiathermy in endoscopic and laparoscopic surgery is discussed, exploring potential risks such as direct and capacitance coupling. The principles behind tissue energizers, specifically advanced bip...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
More News: Cancer & Oncology | Chemotherapy | Laparoscopy | Laparotomy | Pediatrics | Radiation Therapy | Rhabdomyosarcoma | Sarcomas | Soft Tissue Sarcoma | Surgery | Urachal Carcinoma