Cellular Components Contributing to Fibrosis in Endometriosis: A Literature Review

Publication date: Available online 27 November 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Paola Vigano, Jessica Ottolina, Ludovica Bartiromo, Giulia Bonavina, Matteo Schimberni, Roberta Villanacci, Massimo CandianiABSTRACTEndometriosis-related fibrosis represents a complex phenomenon with underlying mechanisms still to be clarified. Fibrosis is consistently present in all disease forms and contributes to classic endometriosis-related symptoms of pain and infertility. The purpose of this literature review was to examine the role of various cellular populations and biological mechanisms/signaling pathways in inducing fibrogenesis of endometriotic lesions. A search was performed through PUBMED and Medline for animal and human studies published in the English language in the last 23 years examining fibrosis in superficial, ovarian, and deep infiltrating endometriosis. The main cell types found to be involved in the development of fibrosis were platelets, macrophages, ectopic endometrial cells, and sensory nerve fibers. Interactions between each of the cell types contribute to the production of fibrosis through the production of soluble factors, mostly transforming growth factor-β but also other cytokines and neuropeptides. Cell types known to be critical to the pathophysiology of endometriosis also contribute to fibrogenesis, thus supporting the theory that fibrosis is an inherent part of endometriosis.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research

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The objective was to evaluate the quality of life and the incidence of depression among women suffering from endometriosis. Afterwards, the dependency between pelvic pain, its severity and stages of endometriosis were analyzed. The study protocol included women of reproductive ages with confirmed endometriosis. The stage of disease was conferred according to the ASRM (American Society of Reproductive Medicine) classification. Women fulfilled two questionnaires: “WERF EPHect Clinical Questionnaire” and self-prepared survey about fertility disorders. The study group comprised of 246 respondents. A total o...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Authors: Pejovic T, Thisted S, White M, Nezhat FR Abstract Endometriosis is a gynecologic disease that affects over 10% of women of reproductive age causing pelvic pain, dysmenorrhea, and infertility, resulting in significant disability and reduced quality of life. Very recent genetic studies have suggested that endometriosis is a clonal disease in the epithelium and its development is independent of stroma, providing new insight into the genesis of endometriosis. The endometrioid tissue lining may also react by epithelial atypical hyperplasia and even neoplasia, in a manner somehow similar to that in the uterine c...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
AbstractEndometriosis is a common benign gynecological condition defined as the presence of endometrial tissue located outside the uterus and frequently associated with chronic pelvic pain and infertility. It is a polymorphic disease that can be presented as superficial implants, endometriomas and deep lesions that infiltrate the peritoneal surface associated with fibrosis and inflammatory reaction. Diagnosis of deep endometriosis is difficult and delayed, frequently missed in a routine ultrasound. Transvaginal ultrasound is the first-line imaging modality to investigate endometriosis and when performed by an expert in fem...
Source: Abdominal Imaging - Category: Radiology Source Type: research
Authors: Mabrouk M, Borghese G, Esposti ED, Raimondo D, Remorgida V, Arena A, Zupi E, Mattioli G, Ambrosio M, Seracchioli R Abstract Endometriosis, defined as the presence of functional endometrial tissue outside the uterine cavity, presents mainly with pelvic pain and infertility. Acute abdominal pain in non-pregnant patients with endometriosis might be minimised as a typical feature of the disease, while endometriosis is rarely considered in the differential diagnosis of acute abdominal pain. Our objective was to conduct a systematic review of the current literature of cases of acute abdomen/acute abdominal pain ...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
A 36-year-old patient was admitted to the emergency room with low abdominal pain and suspected right adnexal mass, and showing a recent positive pregnancy test. She was affected by non-symptomatic pelvic endometriosis and she had three years of infertility. Trans-vaginal ultrasound showed an adenomyotic uterus with a decidualized endometrium without any intrauterine gestational sac. A tubal ring sign on the right adnexa was identified, suggesting an ectopic tubal pregnancy. A 3 cm endometrioma has been identified on the left ovary.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: IMAGES IN Gynecological Surgery Source Type: research
Conclusion Although clinically treated, women with deep endometriosis present impairment in different domains of quality of life regardless of the questionnaire used for evaluation.Resumo Objetivo Descrever caracter ísticas clínicas e sociodemográficas de mulheres com endometriose profunda infiltrativa e avaliar sua qualidade de vida dentro de 6 meses de tratamento clínico. Métodos Estudo de corte transversal descritivo com 60 mulheres em seguimento ambulatorial na Universidade de Campinas, Campinas, SP, Brasil, com endometriose profunda infiltrativa diagnosticada por cirurgia ou mé...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
Endometriosis (EMS) is a multifactorial disease that affects 10% –15% women of reproductive age and is associated with chronic pelvic pain and infertility. The pathogenesis of EMS has not been consistently expl...
Source: Annals of Clinical Microbiology and Antimicrobials - Category: Microbiology Authors: Tags: Research Source Type: research
While his friends were easing into retirement, Thomas D ’Hooghe MD, 55, was sleepless with excitement at the thought of reinventing himself by jumping from academia to pharma.   It is a move he would recommend to anyone. “It was the best thing I ever did,” says the Vice-President and Head Global Medical Affairs, Fertility at Merck, sitting down with me and sharing his thoughts about passion, purpose, leading people and making a difference.  Origins Working in healthcare was always in his blood. In high school it was never a question; D ’Hooghe would study medicine. It was an id...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
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Source: Pediatric Annals - Category: Pediatrics Authors: Tags: Pediatr Ann Source Type: research
CONCLUSIONS: Using robust consensus science methods, healthcare professionals, researchers, and women with endometriosis have developed a core outcome set to standardise outcome selection, collection, and reporting across future randomised controlled trials and systematic reviews evaluating potential treatments for endometriosis. TWEETABLE ABSTRACT: @coreoutcomes for future #endometriosis research have been developed @jamesmnduffy. PMID: 32227676 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
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