Genes which trigger heart disease could one day be 'switched off' by doctors

Scientists at the University of Sheffield have identified a gene named TWIST which they say they could turn off to stop a dangerous artery-blocking condition from developing.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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ConclusionThis statewide study yielded new information on the prevalence of CHDs in adolescents and adults. These high prevalence rates underscore the need for additional specialized care facilities for this population with CHDs.
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 6 December 2019Source: American Journal of Kidney DiseasesAuthor(s): Junichi Ishigami, Yingying Sang, Morgan E. Grams, Josef Coresh, Alex Chang, Kunihiro MatsushitaRationale &ObjectiveInfluenza vaccination is recommended for all adults but particularly for older adults and those with high-risk conditions. Reduced kidney function is an important high-risk condition, but the effectiveness of influenza vaccination across kidney function is uncharacterized. We assessed the effectiveness of influenza vaccination among older adults with and without reduced kidney function.Study DesignObserv...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
CONCLUSIONS.: Prenatal diagnosis increases survival from severe congenital heart disease. However, cyanotic heart diseases and other congenital anomalies, which decrease this chance, should be considered, if surgery is performed or complications occur. PMID: 31800935 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
Authors: Malgutte D, Waghmare I, Bhute V, Joshi A, Gokhale Y Abstract Objective: Study etiology of Non ischemic cardiomyopathy (NICMP) and role of cardiac MRI in diagnosis and outcomes. Methods: prospective observational study. Inclusion Criteria: 1. Clinical feature of cardiac failure, 2. 2D ECHO Systolic dysfunction, EF
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Gupta R, Sharma KK, Soni S, Gupta N, Khedar RS Abstract Background: Hypertension is highly prevalent in India but frequency of resistant hypertension has not been well studied. Methods: We performed a registry-based study at a single center in patients with primary diagnosis of hypertension (n=3073). Details of co-morbidities, medications and blood pressure (BP) control were obtained. Patients with coronary heart disease, cerebrovascular disease and chronic kidney disease were excluded. Resistant hypertension was defined as uncontrolled hypertension (BP ≥140/90) with use of 3 drugs of which one was ...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
ConclusionsWe found significant intercountry variability in cigarette and cannabis use in adults with CHD. Co-use has the most detrimental effects on patient-reported outcomes.RésuméContexteLa prévalence et les effets de la consommation de tabac et de cannabis chez les personnes présentant une cardiopathie congénitale sont mal compris. Nous avons : 1) décrit la prévalence du tabagisme, de la consommation de cannabis et de l’utilisation concomitante de tabac et de cannabis chez des adultes présentant une cardiopathie congénitale; 2) étudié le...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: December 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 12Author(s): Alexander C. Egbe, Rosalyn Adigun, Vidhu Anand, Collin P. West, Victor M. Montori, Hassan M. Murad, Emmanuel Akintoye, Karim Osman, Heidi M. ConnollyAbstractBackgroundAlthough there are robust data about the pathophysiology and prognostic implications of left ventricular (LV) systolic dysfunction in patients with acquired heart disease, similar prognostic data about LV systolic dysfunction are sparse in the tetralogy of Fallot (TOF) population. The purpose of this study was to perform a meta-analysis of all studies that ass...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: December 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 12Author(s): Sarah Cohen, Michelle Z. Gurvitz, Virginie Beauséjour-Ladouceur, Patrick R. Lawler, Judith Therrien, Ariane J. MarelliAbstractAs life expectancy in patients with congenital heart disease (CHD) has improved, the risk for developing noncardiac morbidities is increasing in adult patients with CHD (ACHD). Among these noncardiac complications, malignancies significantly contribute to the disease burden of ACHD patients. Epidemiologic studies of cancer risk in CHD patients are challenging because they require large numbers...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: December 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 12Author(s): Matthias Greutmann, Lee Benson, Candice K. SilversidesAbstractAdult survivors with congenital heart disease are not cured and residual cardiac valve lesions are common and contribute substantially to long-term morbidity. Given the increased risk of reoperations in patients with previous cardiac surgery, percutaneous treatment options have been developed. Initially percutaneous therapies focused on right ventricular outflow tract lesions, but they have now expanded to include mitral and aortic valve interventions. Although s...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: December 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 12Author(s): François-Pierre Mongeon, Laurent Macle, Luc M. Beauchesne, Berto J. Bouma, Markus Schwerzmann, Barbara J.M. Mulder, Paul KhairyAbstractNon-vitamin K antagonist (VKA) oral anticoagulants (NOACs) have several advantages over VKAs that render them an attractive option for adults with congenital heart disease (CHD). Efficacy and safety data specific to the adult CHD population are emerging. Herein, we synthesize the growing literature regarding NOACs in adults with CHD and attempt to identify subgroups for which it appea...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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