Diffuse sclerosing osteomyelitis: A case series and literature review

Diffuse sclerosing osteomyelitis (DSO) is a poorly understood chronic inflammatory disease, for which many aetiological theories and treatment modalities have been suggested. We retrospectively evaluated bisphosphonate treatment outcomes for DSO patients with comparison to alternative treatment modalities and current literature.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Review Article Source Type: research

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We present a case of a Brodie’s abscess in a 52-year-old Crohn’s patient on dual immunosuppres sive therapy.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Adverse Events Related to Therapy Source Type: research
Conclusion: A higher frequency of jaw osteomyelitis secondary to COD was found compared to previous studies. No significant association was shown between any of the COD types and secondary osteomyelitis.Keywords: Cemento-osseous dysplasia, South Africa, patient population.
Source: African Health Sciences - Category: African Health Source Type: research
ConclusionsPatients treated with tedizolid in the outpatient setting experienced a short duration of therapy, low hospital admission, and modest post-index HCRU indicators, suggesting its utility for outpatient therapy of ABSSSIs.
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research
The staphylococcal accessory regulator (sarA) plays an important role in Staphylococcus aureus infections, including osteomyelitis, and the msaABCR operon has been implicated as an important factor in modulating expression of sarA. Thus, we investigated the contribution of msaABCR to sarA-associated phenotypes in the S. aureus clinical isolates LAC and UAMS-1. Mutation of msaABCR resulted in reduced production of SarA and a reduced capacity to form a biofilm in both strains. Biofilm formation was enhanced in a LAC msa mutant by restoring the production of SarA, but this was not true in a UAMS-1 msa mutant. Similarly, extra...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Bacterial Infections Source Type: research
Alveolar bone resection or debridement is a common surgical technique performed in the oral and maxillofacial surgery department for the treatment of chronic osteomyelitis and benign lesions of the bone. The most common complications include incomplete resection of the lesion, because of variations that make it difficult to identify the margin, and injury of the inferior alveolar nerve. Complete removal of necrotic bone is important because of the risk of disease recurrence.1
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
ConclusionThe loss of the ZF-domain and the impaired T cell proliferation accompanied by almost complete persistence of na ïve T cells despite severe infections are suggestive for a profound immunodeficiency. Allogenic HSCT should be considered early for these patients before chronic sequelae occur.
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
Many large series studies have reported that non-tuberculous mycobacteria (NMT) can be attributed to both pulmonary and extrapulmonary diseases. Of the extrapulmonary diseases caused by NMT, skin and soft tissue infection was the most common (Chen et al., 2011). These infections were usually associated with surgical procedures or trauma (Senda et al., 2011; Beam et al., 2014; Legout et al., 2012; Chen et al., 2011). Mycobacteria arupense is an extremely rare cause of soft tissue infection and osteomyelitis.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case Report Source Type: research
Introduction: Osteonecrosis of the jaw (ONJ) is characterized by a chronic wound in the oral mucosa with exposed necrotic bone. This condition may occur following tooth extraction or other types of oral surgery, but may develop spontaneously adjacent to infected teeth or implant. The lesion may be symptomatic but is often asymptomatic. Both irradiation to the head and neck region (osteoradionecrosis) and bacterial infection, mainly Staphylococcus aureus (osteomyelitis), were long been known to cause this phenomenon (1).
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
Conditions:   Bloodstream Infection;   Pneumonia, Bacterial;   Intra-abdominal Infection;   Urinary Tract Infections;   Osteomyelitis;   Central Nervous System Infections;   Acute Bacterial Skin and Skin Structure Infection Intervention:   Diagnostic Test: Detection of CRKp colonization Sponsor:   SCARE (Study group for carbapenem resistance) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
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