Obstructive lung diseases and risk of rheumatoid arthritis.

Obstructive lung diseases and risk of rheumatoid arthritis. Expert Rev Clin Immunol. 2019 Nov 27;: Authors: Friedlander HM, Ford JA, Zaccardelli A, Terrio AV, Cho MH, Sparks JA Abstract Introduction: Smoking is an established risk factor for both lung diseases and rheumatoid arthritis (RA). Chronic mucosal airway inflammation may result in immune tolerance loss, neoantigen formation, and production of RA-related autoantibodies that increase the subsequent risk of RA. In this review, we aimed to summarize the current evidence supporting the role of obstructive lung diseases and subsequent risk of RA.Areas covered: We identified scientific articles discussing the biologic mechanisms linking mucosal airway inflammation and RA risk. We also identified studies investigating asthma, chronic obstructive pulmonary disease, bronchiectasis, cystic fibrosis, chronic tuberculous and nontuberculous mycobacterial infections, and interstitial lung disease with subsequent risk for RA.Expert opinion: The current evidence supports the hypothesis that mucosal airway inflammation may increase the risk of developing RA. However, most studies investigating this relationship have been retrospective and may not have adequately addressed the role of smoking. Larger prospective studies may provide stronger evidence for obstructive lung disease and RA risk. Determining the role of obstructive lung disease in RA pathogenesis may provide opportunity for RA prevention and screening st...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research

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Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
In this study, it is aimed to restrain its proteolytic activity with K23D mutation, which changes lysine (K) residue at the 23rd position to aspartic acid (D). Because we wanted to produce a hassle-free human recombinant immune reactive trypsinogen proenzyme which has similar antigenic properties with the native form. It is also aimed that the mutant IRTs do not exhibit proteolytic activity for the development of durable detection kits with a longer shelf life for both two isoforms. The innovation was actualized in order to use IRTs as a standard antigen in Immunoassays such as ELISA kits. The gene was synthesized as mutat...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
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Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
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Source: Academic Radiology - Category: Radiology Source Type: research
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Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Artificial intelligence is virtually everywhere right now, especially in medtech. But are companies investing in AI just because all the cool kids are doing it, or because of what the technology could ultimately do for healthcare? What is the current state of AI in medtech and what is standing in the way of the technology reaching its full potential? Industry experts will tackle these questions and more at MD&M West in Anaheim, CA on Feb. 11 during a panel session dubbed, "Are AI-Powered Devices Really the Future for Healthcare?" As moderator, I had the opportunity to chat with the panelists this week...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Source Type: news
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Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
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Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Condition:   COPD Interventions:   Device: PulseHaler;   Device: Sham - control Sponsor:   Respinova LTD Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: TMA News Room - Category: Consumer Health News Source Type: news
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