Understanding racial disparities in renal cell carcinoma incidence: estimates of population attributable risk in two US populations

AbstractPurposeRenal cell carcinoma (RCC) incidence is higher among black than white Americans. The reasons for this disparity remain unclear.MethodsWe calculated race- and sex-specific population attributable risk percentages (PAR%) and their 95% confidence intervals (CI) for hypertension and chronic kidney disease (CKD) among black and white subjects  ≥  50 years of age from the US Kidney Cancer Study (USKC; 965 cases, 953 controls), a case–control study in Chicago and Detroit, and a nested case–control study in the Kaiser Permanente Northern California health care network (KPNC; 2,162 cases, 21,484 controls). We also estimated PAR% f or other modifiable RCC risk factors (cigarette smoking, obesity) in USKC.ResultsIn USKC, the PAR% for hypertension was 50% (95% CI 24 –77%) and 44% (95% CI 25–64%) among black women and men, respectively, and 29% (95% CI 13–44%) and 27% (95% CI 14–39%) for white women and men, respectively. In KPNC, the hypertension PAR% was 40% (95% CI 18–62%) and 23% (95% CI 2–44%) among black women and men, and 27% (95% CI 20–35%) and 19% (95% CI 14–24%) among white women and men, respectively. The PAR% for CKD in both studies ranged from 7 to 10% for black women and men but was negligible (
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research

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