The Implementation of Physiological Afterload during Ex Situ Heart Perfusion Augments Prediction of Post-Transplant Function.

The Implementation of Physiological Afterload during Ex Situ Heart Perfusion Augments Prediction of Post-Transplant Function. Am J Physiol Heart Circ Physiol. 2019 Nov 27;: Authors: Gellner B, Xin L, Ribeiro RV, Bissoondath V, Adamson MB, Yu F, Lu P, Paradiso E, Mbadjeu A, Simmons CA, Badiwala MV Abstract Ex Situ heart perfusion (ESHP) is an emerging technique that aims to increase the number of organs available for transplantation by augmenting both donor heart preservation and evaluation. Traditionally, ESHP has been performed in an unloaded Langendorff Mode (LM), though more recently groups have begun to use Pump Supported Working Mode (PSWM) and Passive Afterload Working Mode (PAWM) to enable contractile evaluation during ESHP. To this point, however, neither the predictive effectiveness of the two working modes, nor the predictive power of individual contractile parameters have been analyzed. In this paper, we utilize our previously described system, to analyze the predictive relevance of a multitude of contractile parameters measured in each working mode. Ten porcine hearts were excised and perfused ex situ in LM for four hours, evaluated using pressure-volume catheterization in both PSWM and PAWM and transplanted into size matched recipient pigs. After three hours, hearts were weaned from cardiopulmonary bypass and evaluated. Correlating post-transplant measurements to their ex situ counterparts, we report that parameters measured in both modes sh...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research

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Source: Neurochemistry International - Category: Neuroscience Source Type: research
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Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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