The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers.

CONCLUSIONS: These results show 4-MP effectively reduced oxidative metabolism of APAP in human volunteers ingesting a supratherapeutic APAP dose. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03878693. PMID: 31768936 [PubMed - as supplied by publisher]
Source: Journal of Medical Toxicology - Category: Toxicology Authors: Tags: J Med Toxicol Source Type: research

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Publication date: Available online 22 January 2020Source: Journal of Forensic and Legal MedicineAuthor(s): Karen Eline van den Hondel, Priscilla Punt, Tina Dorn, Manon Ceelen, Udo ReijndersAbstractIntroductionThe three ‘advised’ suicide methods are helium asphyxiation, voluntarily stop eating and drinking and the use of a deadly dose of medication such as barbiturates. The aim of this study was to analyse the number of suicides resulting from barbiturate overdose and examine the influence of publications and internet on this suicide method in the two larger cities of the Netherlands.MethodsData of suicides by m...
Source: Journal of Forensic and Legal Medicine - Category: Forensic Medicine Source Type: research
This article includes references to self-injury, intravenous drug use and disordered eating.* One in five US high school students have reported being bullied. Approximately 160,000 teenagers have skipped school as a preventative measure. I encountered bullies for the first time in second grade, in the midst of such an innocent time of my youth. I dreaded entering my elementary school classroom, as I was well aware of what my presence would entail. I endured both verbal and physical harassment from my fellow peers for nearly a decade. I was passive, inevitably leading to the acceptance of my “fate,” in addition ...
Source: Psych Central - Category: Psychiatry Authors: Tags: Addictions Anorexia Bullying Depression Eating Disorders Personal Stories Substance Abuse Addiction Recovery Anorexia Nervosa Drug Use heroin Self Harm Self Injury Source Type: news
CONCLUSIONS: Our case showed that an overdose of an SGLT2 inhibitor caused toxic effects on renal function, but severe hypoglycemia was not observed. Additional cases of intoxication from SGLT2 inhibitors alone would be helpful to clarify the mechanism of intoxication. PMID: 31918741 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Conclusions: Nearly half of those with tranquilizer misuse in a general population sample were categorized into one of two high polysubstance use classes, and these two classes were associated with poorer functioning. Findings from these analyses underscore the need to reduce polysubstance use among those who misuse tranquilizers. PMID: 31900021 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
The majority of opioid-related deaths are accidental. However, the number of opioid-related suicidal deaths is likely under recognized. Presented here is a case of suicide by heroin overdose. The manner of death would have likely been deemed accidental if ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Abstract The majority of opioid-related deaths are accidental. However, the number of opioid-related suicidal deaths is likely under recognized. Presented here is a case of suicide by heroin overdose. The manner of death would have likely been deemed accidental if not for critical information shared by the decedent's family during follow-up telephone interviews between the forensic pathologist and the decedent's family, which included text messages that were sent by the decedent just before his death that were not known at the time of the initial medicolegal death scene investigation. This case highlights that whe...
Source: Journal of Forensic Sciences - Category: Forensic Medicine Authors: Tags: J Forensic Sci Source Type: research
Conclusions: In patients with PTSD and OUD, improved adherence to MAT and greater exposure to general substance abuse care may result in lower mortality. Studies with longer follow-up and larger sample sizes to assess the impact of MAT on suicide are needed to confirm our findings. PMID: 31852392 [PubMed - as supplied by publisher]
Source: Journal of Dual Diagnosis - Category: Addiction Tags: J Dual Diagn Source Type: research
This study aims to identify predictors of suicide in patients with suicidal attempt retry (SAR), who are followed-up an in the Intensive Intervention Program (PII).MethodsThe sample includes patients followed up at the PII because of a previous suicidal attempt. The following variables were collected during the 12 months follow-up (baseline, 6 months and 12 months): Repeated attempts, socio-demographic and clinical variables, lack of adherence and the Beck Depression Inventory and Hopelessness Scale.Statistic analysisThe association between SAR and qualitative study variables was performed using Chi-Square and for the quan...
Source: Revista de Psiquiatria y Salud Mental - Category: Psychiatry Source Type: research
CONCLUSIONS: The results highlight a particular population of problematic ketamine users identified using the hospital's ICT system. In particular, poly-drug users who consume ketamine in combination with heroin or cocaine presenting to the ED represent a specific target for targeted prevention projects on non-lethal overdoses and suicide attempts. PMID: 31850860 [PubMed - in process]
Source: Annali dell Istituto Superiore di Sanita - Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research
Conclusions: DUIMS indicates higher mortality, and DUIMS' profiles in causes of death differ from the general population. Elevated risk for, for instance, suicidal, accidental and violent death among those using multiple substances highlights the need to also pay attention to causes of death other than poisoning/overdose. PMID: 31856686 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Public Health - Category: International Medicine & Public Health Authors: Tags: Scand J Public Health Source Type: research
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