The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers.

CONCLUSIONS: These results show 4-MP effectively reduced oxidative metabolism of APAP in human volunteers ingesting a supratherapeutic APAP dose. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03878693. PMID: 31768936 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31768936?dopt=Abstract

Source: Journal of Medical Toxicology - November 24, 2019 Category: Toxicology Authors: Kang AM, Padilla-Jones A, Fisher ES, Akakpo JY, Jaeschke H, Rumack BH, Gerkin RD, Curry SC Tags: J Med Toxicol Source Type: research