Correlation between gene polymorphism and opioid efficacy in patients with gastric or intestinal cancer.

Correlation between gene polymorphism and opioid efficacy in patients with gastric or intestinal cancer. Eur Rev Med Pharmacol Sci. 2019 Nov;23(21):9393-9410 Authors: Pu J, Wang N, Huang ZK, He XY, Yuan HB Abstract OBJECTIVE: To explore the correlation between gene polymorphism and opioid efficacy in patients with gastric or intestinal cancer. PATIENTS AND METHODS: Fifty-nine patients who underwent laparoscopic surgery for gastric or intestinal cancer under general anesthesia were included and randomly divided into oxycodone (n=30) and sufentanil groups (n=29) by reproducible random number generation method. Single nucleotide polymorphisms (SNPs) of four alleles: μ-opioid receptor gene OPRM1 A118G, cytochrome P450 (CPY450) enzyme system: CPY3A4*1G, CYP3A5*3, and CYP2D6*10 were detected by PCR-pyrosequencing. Patients in sufentanil group received intravenous sufentanil injection during anesthesia induction, intraoperative maintenance, and postoperative analgesia, while those in oxycodone group received oxycodone. Patients' postoperative VAS score, opioid use, and prevalence of adverse reactions were recorded. RESULTS: The genotype distribution of OPRM1 A118G, CYP3A4*1G, CYP3A5*3, and CYP2D6*10 in Chinese gastric cancer/intestinal cancer patients accorded with the Hardy-Weinberg law (p>0.05). OPRM1 A118G polymorphism correlated with postoperative VAS score and medication dosage, in oxycodone group (p0.05). The total intraoperative medication i...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

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Conclusions: Magnesium sulfate is an important adjuvant drug in the practice of anesthesia, with several clinical effects and a low incidence of adverse events when used at recommended doses. Introduction Magnesium is the fourth most common ion in the body, and it participates in several cellular processes, including protein synthesis, neuromuscular function and stability of nucleic acid, as well as regulating other electrolytes such as calcium and sodium. Magnesium acts as a cofactor in protein synthesis, neuromuscular function and stability and the function of nucleic acids. It is a component of adenosine 5-triph...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
 Everyone has bad habits. Even your sainted Granny who seems perfect to you has some bad habit that only your grandfather knows about. Bad habits, like everything, exist on a spectrum, from biting your nails to snorting cocaine – and everything in between. In this episode, our hosts discuss bad habits that many people with mental illness seem to have – from smoking, to alcoholism, to drug use and, you guessed it, everything in between.   SUBSCRIBE &REVIEW “90% of people with schizophrenia smoke.” – Michelle Hammer   Highlights From ‘Bad Habits Mental Illness&rsq...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Addiction Habits Schizophrenia Stress Source Type: blogs
In conclusion, the reduction in the analgesic action of opioids in DNP might be a consequence of MOR reduction, particularly in the spinal cord. Therefore, developing opioids of high efficacy might provide analgesia exceeding that of currently available opioids. Introduction Neuropathic pain (NP) is a chronic pain condition that limits patients to fully achieve their daily tasks. Consequently, NP has significant impact on the economic welfare of the society (Bouhassira et al., 2008; Gaskin and Richard, 2012). Therefore, to find drugs satisfactorily treating NP is a major clinical goal. The management of severe acut...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Research Source Type: news
BOSTON (CBS) — “Jeopardy!” host Alex Trebek announced Wednesday that he is battling stage 4 pancreatic cancer.  A Message from Alex Trebek: pic.twitter.com/LbxcIyeTCF — Jeopardy! (@Jeopardy) March 6, 2019 The 78-year-old Trebek, who has hosted the popular quiz show since 1984, vowed to keep working and said “I plan to beat the low survival rate statistics for this disease.” WBZ-TV’s Dr. Mallika Marshall sat down with David Wade and Lisa Hughes to answer questions about this deadly cancer. What Is The Pancreas? It’s an organ that sits behind the stomach. It produces ho...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated Local Alex Trebek Dr. Mallika Marshall Pancreatic Cancer Source Type: news
ConclusionsCancer survivors in rural China have deteriorated HRQoL, and a substantial number of survivors have pain/discomfort problems. Our study provides detailed data on HRQoL of rural cancer survivors for future supportive and survivorship care in China.
Source: Quality of Life Research - Category: Health Management Source Type: research
Younger women are having more heart attacks, and accounted for nearly a third of all female heart attack patients in recent years, according to a recent study. The news compounds a string of recent findings that have pointed to poorer overall health for young American women. “Women now, compared to younger women generations before them, are less healthy,” says study co-author Melissa Caughey, a cardiovascular epidemiologist and instructor at the University of North Carolina Chapel Hill School of Medicine. “It’s probably reflective of poorer health in general.” The study, which appeared in a sp...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime Research Source Type: news
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Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Detox gluten-free grain-free grains Inflammation Weight Loss Source Type: blogs
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Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
Discussion of advocacy for the cause is a usual feature of our community, as we try things and attempt to make progress in persuading the world that rejuvenation research is plausible, practical, and necessary. There are more people engaged in advocacy now than at any time in the past decade, and so discussions of strategy come up often. New ventures kicked off in 2017 include the Geroscience online magazine, and among the existing ventures the LEAF / Lifespan.io volunteers seem to be hitting their stride. The mainstream media continues to be as much a hindrance as a help, and where it is a help you will usually find Aubre...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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