Placental infection by Zika virus in French Guiana.

CONCLUSIONS: Early placentomegaly may represent the first sign of trans-placental contamination and should lead to an enhanced follow-up of these pregnancies. This article is protected by copyright. All rights reserved. PMID: 31773804 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research

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Asisa Volz In 2015 Zika virus (ZIKV) emerged for the first time in South America. The following ZIKV epidemic resulted in the appearance of a clinical phenotype with microcephaly and other severe malformations in newborns. So far, mechanisms of ZIKV induced damage to the fetus are not completely understood. Previous data suggest that ZIKV may bypass the placenta to reach the fetus. Thus, animal models for ZIKV infection are important to facilitate studies about ZIKV infection during pregnancy. Here, we used ultrasound based imaging (USI) to characterize ZIKV induced pathogenesis in the pregnant Type I interferon recep...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Conclusion We found no differences in pregnancy or neonatal outcomes between women who tested positive and presumed positive for Zika virus during pregnancy. Testing of infants and placenta tissue after delivery was largely inconclusive. Improvement in testing for Zika virus infection is needed to determine which pregnancies are at risk for congenital anomalies. Further research is still needed to determine which children are at risk for poor neurodevelopmental outcomes related to Zika virus and how to best coordinate care among the immigrant population during a new disease epidemic. [...] Thieme Medical Publishers 33...
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
Conclusions Apart West Nile virus (78), thousands of congenital microcephaly cases, fetal brain tissue damage and neurological syndromes have been associated with ZIKV infection. Unfortunately, the epidemics of this mosquito born, and a relative stable virus is on a rise. Although congenital microcephaly is a rare disorder however, due to lack of standardized diagnostic test facilities, the incidence in the geographically widespread ZIKV epidemic regions is higher. Animals studies showed that ZIKV is a neurotropic virus. It directly targets the developing embryonic brain cells by inducing apoptosis, cell-cycle arrest, and...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This article is protected by copyright. All rights reserved. PMID: 30561172 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
Conclusion The awareness campaign on zika virus had a significant impact on population’s knowledge and main practical information was correctly captured. The information did not spill excessive fear. Nevertheless, modification of individual behavior appeared harder to obtain.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
CONCLUSIONS: In the population of women screened by this questionnaire, 5.1% traveled internationally and 39.6% traveled domestically prior to their anatomic ultrasound. Notably, Florida and Texas are common travel destinations among women at this clinic, and both have had active local transmission of Zika virus. PMID: 29357209 [PubMed - in process]
Source: WMJ - Category: General Medicine Authors: Tags: WMJ Source Type: research
The most recent outbreak of Zika Virus (ZIKV) began April 2015 in Brazil and has spread to the majority of countries in Latin America and the Caribbean (LAC). Emerging in vitro and epidemiologic evidence has indicated a strong link between ZIKV infection in pregnancy and severe adverse effects on fetal development, some of which may be detected during obstetric ultrasound. However, it is unknown whether obstetric ultrasound services and referral networks have adequate capacity to detect and appropriately refer suspected cases of Congenital Zika Syndrome (CZS) in LAC.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: IDSOG Abstract Source Type: research
This study was based upon a small number of cases and ultrasound detection rather than births. Seven cases of microcephaly were reported above background, but only one of them was a birth; the others were detected by ultrasound. The high rate of ultrasound detection is not consistent with observations by ultrasound of microcephaly in other countries, including Colombia. We use the model for French Polynesia as a reference model for comparison with other data in order to clarify which data is or is not consistent with that model. We note that this rate is about 100 times larger than the minimum reported background rate for ...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
We report the results of a rapid assessment of Zika virus awareness among key clinical specialties in Singapore, with the aim of identifying gaps in knowledge and opportunities for improving communication on Zika virus disease management and control policies. Methods Study Participants and Sites Between June 6 and June 19, 2016 prior to the Zika virus outbreak, we conducted an online survey of doctors working in obstetrics and gynaecology, neonatology and paediatrics in Singapore. A link to the online survey was disseminated by email to the relevant doctors at KK women’s and Children’s Hospital and Singapo...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
This study included more recent evidence compared to the previous one. The Bradford-Hill Viewpoints are used in public health to determine causation of diseases.11 Systematic application of the viewpoints can assist with analysing a possible causal relationship. Additional studies to assess the risk of microcephaly in affected pregnant mothers are ongoing.12 In this study we applied the Bradford-Hill viewpoints to investigate the association between Zika virus and Microcephaly. Method Using the Bradford Hills nine viewpoints we analysed data from a 2013 outbreak in French Polynesia and the 2015 Brazilian outbreak to esta...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
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