Tuina Massage Improves Cognitive Functions of Hypoxic-Ischemic Neonatal Rats by Regulating Genome-Wide DNA Hydroxymethylation Levels.

Tuina Massage Improves Cognitive Functions of Hypoxic-Ischemic Neonatal Rats by Regulating Genome-Wide DNA Hydroxymethylation Levels. Evid Based Complement Alternat Med. 2019;2019:1282085 Authors: Zhang Y, Gao C, Chen D, Wang C, Chen L, Zhang Y, Li B Abstract In addition to abnormalities of motor and posture, children with cerebral palsy (CP) often have intellectual disability. As a complementary and alternative traditional Chinese medicine (TCM) therapy, Chinese Tuina massage, also called Tuina in China, has been widely applied in clinical treatment for CP in China for a long time. However, the molecular basis for this still remains largely unknown. Recently, DNA hydroxymethylation has been shown to be sensitive to environment and plays critical roles in some neurological disorders, whereas the research focusing on the relationship between 5 hmC and Tuina therapy for cerebral palsy is deficient. In our study, we first observed that Tuina improved learning and memory functions of hypoxic-ischemic (HI) rat pups. Meanwhile, 5 hmC level of the temporal lobe cortex in the HI neonatal rat model is decreased significantly compared to that of the rats in control and Tuina groups. Then, we used the hMeDIP-Seq method to explore whether and how DNA hydroxymethylation is involved in Tuina therapy for cerebral palsy. Genomic annotation of DhMRs of HI group's hypo-hydroxymethylation to genes revealed enrichment in multiple neurodevelopmental signaling pa...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

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Children with intellectual disability frequently undergo gastrostomy in order to continue enteral feeds. Indications for gastrostomy include failure to thrive, dysphagia and pulmonary aspiration, or even oral aversion. These children often have complex, comorbid conditions, such as cerebral palsy, seizures, or cardiopulmonary dysfunction. Parents are thus often challenged by the decision whether to proceed with gastrostomy, as a feeding tube will change daily care and long-term outcome for their child.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
Conclusions Stabilization exercises could improve the voluntary activity of transverse abdominal muscle of mothers of children with cerebral palsy.
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
Sometimes the best goals are soft and squishy like an eggnog filled belly.It’s either very late or very early, depending on your point of view. Either way, I’m sitting here thinking deep, New Year’s-like thoughts. In the other room sleeps a friend who almost wasn’t my friend anymore until we patched things last week. Upstairs sleeps my third daughter whose heart is in need of mending as her marriage comes to an end. Hanging out with dad and his friend on New Year’s Eve was either a low point for her or just exactly what she needed.My thoughts are a warm blend of nostalgia and regret with a sub...
Source: The Splintered Mind by Douglas Cootey - Category: Psychiatry Tags: ADHD Depression Family Goodreads Journaling Source Type: blogs
A video has gone viral of Kinley Jones, four, of Fayetteville, North Carolina, who has the motor disability, learning how to walk as ditches the walker and begins walking towards her mother.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusions: Given the importance of accuracy in height measures to evaluate infant health, it is crucial to carry out more researches in order to safely establish an association between both estimate and real statures. The development of anthropometric protocols, emerged from such researches, would benefit the follow-up of children with severe psychomotor disabilities.RESUMO Objetivo: Revisar estudos que avaliam correspond ência entre a altura estimada por medidas segmentares e a estatura real de crianças com paralisia cerebral. Fonte de dados: Revisão sistemática da literatura entre 1995 e 2018...
Source: Revista Paulista de Pediatria - Category: Pediatrics Source Type: research
In conclusion, school-aged children with CP very often screened positive for ASD and/or ADHD. The prevalence of ASD and ADHD is most likely underestimated in children with CP. These screening findings require further investigations.
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
BACKGROUND: Cerebral palsy (CP) is a common disability in children featured with pathological gait and limb function limitation due to muscle weakness. Improving limb function and quality of life is currently considered to be highlighted. Physiotherapy is ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Conclusion: The Goldsmith Indices of Body Symmetry has good inter and intra-rater reliability for measurement of thoracic shape and symmetry, pelvic orientation and hip range, allowing accurate tracking of postural changes over time in non-ambulant adults with cerebral palsy.Implications for rehabilitationThe Goldsmith Indices of Body Symmetry is a reliable clinical measurement tool to enable measurement of the thoracic shape and symmetry, pelvic and hip orientation in adults with cerebral palsy.The Goldsmith Indices of Body Symmetry, with an impairment focus, is a useful adjunct to the assessment and management of postura...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
DiscussionThis is the first trial evaluating the efficacy and safety of scalp acupuncture as a treatment for motor dysfunction in children with cerebral palsy. The results of this trial are expected to provide relevant evidence demonstrating that scalp acupuncture can be used as an effective rehabilitation treatment method for improving motor dysfunction in children with cerebral palsy.Trial registrationClinicalTrials.gov,NCT03921281. Registered on 19 April 2019.
Source: Trials - Category: Research Source Type: clinical trials
Conclusions: The combination of Factor and Rasch analysis along with consultation with patients, clinicians and experts in health-related quality-of-life instrument development, has resulted in a short version of the Cerebral Palsy quality of life instrument.IMPLICATION FOR REHABILITATIONThis study provides the first classification system for children with Cerebral Palsy.The Cerebral Palsy-six dimension (CP-6D) survey, which is a short version of Cerebral Palsy Quality Of Life instrument, can be timesaving when measuring quality of life in children with Cerebral Palsy.The short version (CP-6D) can be used in preference bas...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
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