1,25(OH)2D3 in Brain Function and Neuropsychiatric Disease.

1,25(OH)2D3 in Brain Function and Neuropsychiatric Disease. Neurosignals. 2019;27(1):40-49 Authors: Lang F, Ma K, Leibrock CB Abstract 1,25(OH)2D3 (1,25-dihydroxy-vitamin D3 = calcitriol) is a powerful regulator of mineral metabolism. The hormone increases calcium and phosphate plasma concentrations in part by stimulation of intestinal absorption and renal reabsorption of calcium and phosphate. It is primarily, but not exclusively, produced in the kidney. Renal 1,25(OH)2D3 formation is stimulated by calcium and phosphate deficiency and by parathyroid hormone which is up-regulated by hypocalcemia. 1,25(OH)2D3 formation is inhibited by fibroblast growth factor FGF23, which is up-regulated by phosphate excess and requires Klotho to become effective. Klotho- or FGF23-deficiency leads to excessive plasma 1,25(OH)2D3-, Ca2+- and phosphate-concentrations with severe soft tissue calcification and accelerated aging. Tissue calcification and premature aging are prevented by NH4Cl without affecting 1,25(OH)2D3-formation. 1,25(OH)2D3 has powerful effects apparently unrelated to mineral metabolism, including anti-inflammatory actions and modification of multiple brain functions. Excessive 1,25(OH)2D3 formation in klotho-deficient NH4Cl-treated mice leads to an amazing surge of exploratory behavior, lack of anxiety and decreased depression, effects dissipated by low vitamin D diet. Conversely, vitamin D deficient mice display reduced explorative behavior, enhanced anx...
Source: Neuro-Signals - Category: Neurology Authors: Tags: Neurosignals Source Type: research

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CONCLUSIONS: These findings suggest that careful clinical history taking to document specific neurodevelopmental features may be informative in screening for individuals with schizophrenia who are at higher risk of carrying known SCZ-associated CNVs. Identification of genomic disorders in these individuals is likely to have clinical benefits similar to those demonstrated for other neurodevelopmental disorders. PMID: 31964429 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
Authors: Conwell Y PMID: 31964547 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
In conclusion, data revealed no correlation between ex vivo and in vivo studies explained by the collapse of the follicles in ex vivo skin permeation study, leaving only the lipoidal pathway for NE to pass through, thus only NE components, neither nanosizing nor other reported mechanisms, are the main influencing factors. In vivo experiments suggested that o/w NE changed ATOR pathway to follicular delivery leading to accumulation of NE in follicles and consequently a prolonged plasma profile.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
In this study, a novel vitamin E succinate-based formulation of Ir (VES-Ir) combined with nanoscaled characteristics and synergistic combination was constructed through esterification. The conjugation makes amphiphilic VES-Ir prodrug self-assemble into nanoparticles with a fine diameter (VES-Ir NPs, 75.4 nm) of spherical morphology. Furthermore, VES-Ir NPs with a 1:1 drug-to-drug ratio was demonstrated to possess respectable physiological stability within 72 h test, while can react to pH/esterase-sensitive drug release in lysosomes internalized into tumor cells, potentially highlighting their alleviating side effects. Comp...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: April 2020Source: Biomedicine &Pharmacotherapy, Volume 124Author(s): Cheol Woo Park, Ji Hyeon Ahn, Tae-Kyeong Lee, Young Eun Park, Bora Kim, Jae-Chul Lee, Dae Won Kim, Myoung Cheol Shin, Yoonsoo Park, Jun Hwi Cho, Sungwoo Ryoo, Young-Myeong Kim, Moo-Ho Won, Joon Ha ParkAbstractOxcarbazepine (OXC), a voltage-gated sodium channel blocker, is an antiepileptic medication and used for the bipolar disorders treatment. Some voltage-gated sodium channel blockers have been demonstrated to display strong neuroprotective properties in models of cerebral ischemia. However, neuroprotective effects and mechanisms o...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 23 January 2020Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Nadja Rifaie, Fuat H. SanerAbstractAcute liver failure is defined as severe hepatic dysfunction (marked transaminases elevation, detoxification disorder (jaundice and coagulopathy with INR> 1.5)Presence of hepatic encephalopathy and exclusion of underlying chronic liver disease and a secondary cause like sepsis or cardiogenic shock.Reasons for acute liver failure includes paracetamol -and warfarin toxicity, autoimmune – and viral (mainly hepatitis B and E) hepatitis, herbal and dietary supplemen...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
This study is registered on PROSPERO, number CRD42017078611.FindingsOf 8122 records identified, 21 were eligible and data were available for 15 RCTs, all of which had a low to moderate risk of overall bias. Anxiety (five interventions, 728 participants) showed a greater response to intervention among women reporting intimate partner violence than among those who did not (difference in standardised mean differences [dSMD] 0·31, 95% CI 0·04 to 0·57, I2=49·4%). No differences in response to intervention were seen in women reporting intimate partner violence for PTSD (eight interventions, n=1436; dS...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
In the article “Structural Brain Alterations in Youth With Psychosis and Bipolar Spectrum Symptoms,” by Jalbrzikowski et al., published in the November 2019 issue of the Journal of the American Academy of Child and Adolescent Psychiatry (2019;58:1079-1091), Table 2 included duplicated values for cortical thi ckness and surface area measurements. In the updated Table 2 below, the duplication has been removed.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Tags: Correction Source Type: research
Publication date: Available online 23 January 2020Source: NeurocomputingAuthor(s): Jing Lin, Weike Pan, Lin Li, Zixiang Chen, Zhong MingAbstractThe spreading use of the Internet and big data technology has spawned the need for recommendation systems. However, to alleviate public anxiety about privacy, this paper advocates making recommendation with internal context, which refers to the implicit context hidden beneath the rating matrix only. Inspired by a recent work that embeds neighborhood information among users (as represented by multiclass preference context, MPC) into a factorization-based method, we extend it to both...
Source: Neurocomputing - Category: Neuroscience Source Type: research
ConclusionThe use of BP in HRV analysis can help in the monitoring of somatic distress and depression issues in SSD cases. LF, RMSSD, PSI are potential physiological indicators.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
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