Simvastatin Evokes An Unpredicted Antagonism For Tamoxifen In MCF-7 Breast Cancer Cells

Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

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AbstractBackgroundThere are a limited number of studies investigating the relationship between primary care physician (PCP) characteristics and the quality of care they deliver.ObjectiveTo examine the association between PCP performance and physician age, solo versus group affiliation, training, and participation in California ’s Affordable Care Act (ACA) exchange.DesignObservational study of 2013-2014 data from Healthcare Effectiveness Data and Information Set (HEDIS) measures and select physician characteristics.ParticipantsPCPs in California HMO and PPO practices (n = 5053) with part of their patient...
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
Survivin has an anti-apoptotic effect against anthracycline-induced cardiotoxicity. Clinically, statin use is associated with a lower risk for heart failure in breast cancer patients with anthracycline chemotherapy. So, the purpose of our study was to investigate whether survivin mediates the protective effect of statin against anthracycline-induced cardiotoxicity.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research
In this study, we explored the anti-tumour mechanisms of a lipophilic statin, lovastatin, in MCF-7 breast cancer cells. Lovastatin inhibited cell proliferation and induced cell apoptosis. Lovastatin caused p21 elevation while reduced cyclin D1 and survivin levels. Lovastatin also increased p53 phosphorylation, acetylation and its reporter activities. Results from chromatin immunoprecipitation analysis showed that p53 binding to the survivin promoter region was increased, while Sp1 binding to the region was decreased, in MCF-7 cells after lovastatin exposure. These actions were associated with liver kinase B1 (LKB1), AMP-ac...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
Conclusions: Many of the trials that have established the efficacy and safety of statins were conducted predominantly or entirely in men, with results extrapolated to women. Additional research is needed to guide clinical recommendations specific to women. Video Summary:
Source: Menopause - Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research
Palbociclib is a selective well-tolerated antineoplastic drug used in the treatment of advanced HER2-negative, estrogen-receptor positive breast cancer that has shown significant improvement in progression-fre...
Source: BMC Neurology - Category: Neurology Authors: Tags: Case report Source Type: research
In conclusion, our results suggest that SIM may serve as a promising treatment with TAM for improving the efficacy against estrogen receptor-positive (ER+) breast cancer.Graphical abstract
Source: Toxicology Reports - Category: Toxicology Source Type: research
Results could cause patients undue worry or inappropriate reassurance – and increase workload for GP teams Related items fromOnMedica Doctors campaign against ‘too much medicine’ NHS must improve access to screening to save lives Metastatic breast cancer goes undiagnosed for too long Statins of small and uncertain benefit in primary prevention Pharmacists could offer high-dose statins direct to patients
Source: OnMedica Latest News - Category: UK Health Source Type: news
(CNN) — Leading nutritional experts in the United States and the UK are fired up about new dietary recommendations claiming there’s no need to reduce your red and processed meat intake for good health. “This is a very irresponsible public health recommendation,” said Dr. Frank Hu, who chairs the nutrition department at the Harvard T.H. Chan School of Public Health. The new guidelines and five corresponding studies are part of a systematic analysis of existing research done by NutriRECS, a recently formed international group of nutritionists and health researchers. NutriRECS says its mission is to &l...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated CBSN Boston Syndicated Local CNN Red Meat Source Type: news
ConclusionsThese analyses suggest the pharmacokinetic profile of darolutamide is not affected by a number of commonly administered drugs in patients with nmCRPC. Although pharmacokinetic data have indicated that darolutamide has the potential to interact with rosuvastatin, used to assess DDI in these studies, this finding did not seem to translate into increased AEs due to statin use in the ARAMIS identifier: NCT02200614.
Source: Targeted Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: The abnormal location of FLT3 caused by different glycosylation status leads to the distinguishing signaling pathways. Targeting on FLT3 glycosylation may provide a new perspective for therapeutic strategies. Abbreviations: ABCG2: ATP-binding cassette transporter breast cancer resistance protein; ATF: activating transcription factor; AML: acute myeloid leukemia; CHOP: CCAAT-enhancer-binding protein homologous protein; 2-DG: 2-deoxy-D-glucose; EFS: event free survival; EPO: erythropoietin; EPOR: erythropoietin receptor; ERS: endoplasmic reticulum stress; FLT3: FMS-like tyrosine kinase 3; GPI: glycosylphosphatid...
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
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