IFN β treatment inhibits nerve injury-induced mechanical allodynia and MAPK signaling by activating ISG15 in mouse spinal cord

Interferons (IFNs) are a class of cytokines originally detected in immunological cells, but have since been shown to be produced during non-immunological responses of both central and peripheral origins. IFNs regulate antiviral and immunomodulatory responses as well as cell growth in immune cells (lymphocytes and macrophages) and non-immune target cells from epithelial and nervous tissues.10,12,34,61,62 There are two major types of IFNs: type I consists chiefly of IFN α and IFNβ, and also IFNω, IFNδ, and IFNτ, whereas type II consists of a single type, IFNγ.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Original Reports Source Type: research