Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes

Bile acids (BAs) are signaling molecules controlling lipid and glucose metabolism. Since BA alterations are associated with obesity and insulin resistance, plasma BAs have been considered candidates to predict type 2 diabetes (T2D) risk. We aimed to determine (1) the association of BAs with glucose homeostasis parameters and (2) their predictive association with the risk of conversion from prediabetes to new-onset diabetes (NOD) in a prospective cohort study.

Source: Metabolism - Clinical and Experimental - November 26, 2019 Category: Biomedical Science Authors: Oscar Ch ávez-Talavera, Matthieu Wargny, Matthieu Pichelin, Amandine Descat, Emmanuelle Vallez, Mostafa Kouach, Edith Bigot-Corbel, Marielle Joliveau, Jean-Francois Goossens, Cédric Le May, Samy Hadjadj, Rémy Hanf, Anne Tailleux, Bart Staels, Bertrand Source Type: research