Equilibrium solubility, solvent effect and preferential solvation of 5-nitrofurazone (form γ) in aqueous co-solvent mixtures of isopropanol, N-methyl pyrrolidone, ethanol and dimethyl sulfoxide

Publication date: Available online 26 November 2019Source: The Journal of Chemical ThermodynamicsAuthor(s): Yuxin Bao, Ali Farajtabar, Min Zheng, Hongkun ZhaoAbstractSolubilities of 5-nitrofurazone (form γ) in aqueous co-solvents mixtures of isopropanol, N-methyl pyrrolidone (NMP), ethanol and dimethyl sulfoxide (DMSO) were experimentally investigated via the saturation shake-flask technique at temperatures from 278.15 K to 323.15 K under ambient pressure of p=101.2 kPa. The solubility of 5-nitrofurazone increased to a maximum value with 100 % mass fractions of NMP and DMSO in aqueous solutions of NMP and DMSO, while with 80 % mass fractions of isopropanol and ethanol in aqueous solutions of isopropanol and ethanol. The solids equilibrated with liquor were characterized by X-ray power diffraction, indicating that no solvate formation or polymorphic transformation occurred. The Jouyban-Acree model was accepted to correlate the obtained solubility. The acquired highest relative average deviation and root-mean-square deviation values were, respectively, 5.62×10-2 and 11.18×10-4. Quantitative values for local mole fractions of NMP (ethanol, DMSO, DMF or isopropanol) and water nearby 5-nitrofurazone were obtained by the method of Inverse Kirkwood–Buff integrals. The parameters of preferential solvation were positive for isopropanol/ethanol in the isopropanol/ethanol mixtures in intermediate compositions, and for NMP/DMF/DMSO in the NMP/DMF/DMSO mixtures in intermediate and NM...

Source: The Journal of Chemical Thermodynamics - November 28, 2019 Category: Chemistry Source Type: research