Non ‐alcoholic fatty liver disease in men

Non ‐alcoholic fatty liver disease (NAFLD) is becoming a significant clinical and economic burden globally. It affects more men than women for reasons that are not yet completely understood. If identified in the early stages and treated, NAFLD can be reversed. Here the authors review the diagnosis and management of NAFLD in men.
Source: Trends in Urology and Men's Health - Category: Urology & Nephrology Authors: Tags: Liver disease Source Type: research

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Patients with non-alcoholic fatty liver disease (NAFLD) and increased liver-fibrosis scores experience more severe illness from COVID-19, according to a study of Chinese patients.Reuters Health Information
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Gastroenterology News Source Type: news
We read with great interest the review by Tr épo and Valenti on recent developments in genetics of NAFLD,1 which highlighted the need for further confirmation of the association between the rs2642438 (p.A165T) variant in the mitochondrial amidoxime reducing component 1 (MARC1) gene and liver disease risk. This missense variant was recently sh own to associate with protection from all-cause cirrhosis.2 MARC1 encodes for a molybdenum-containing enzyme in the outer mitochondrial membrane, which has reductive activity for N-hydroxylated compounds, e.g.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
ConclusionsThe present study showed that the decrease of visceral fat area and the increase of adiponectin level contributed to the improvement of NAFLD in patients with type  2 diabetes mellitus. Furthermore, dapagliflozin and pioglitazone exerted equivalent beneficial effects on NAFLD in patients with type 2 diabetes mellitus, although it seemed that these two drugs had different mechanisms of action.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Clinical Trial Source Type: research
Fat accumulation in the liver contributes to the development of non-alcoholic fatty liver disease (NAFLD). N-acetylcysteine (NAC) is an antioxidant, acting both directly and indirectly via upregulation of cell...
Source: Lipids in Health and Disease - Category: Lipidology Authors: Tags: Research Source Type: research
Publication date: Available online 23 May 2020Source: Journal of EthnopharmacologyAuthor(s): Seong-hwan Park, Jung-Eun Lee, So Min Lee, Jueun Lee, Chang-Seob Seo, Geum-Sook Hwang, Jeeyoun Jung
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Alcohol dehydrogenase 1B (ADH1B) is involved in alcohol metabolism. The allele A (ADH1B*2) of rs1229984: A>G variant in ADH1B is associated a higher alcohol metabolizing activity, compared to the ancestral allele G (ADH1B*1). Moderate alcohol consumption is associated with reduced severity of nonalcoholic fatty liver disease (NAFLD), based on histologic analysis, compared with no alcohol consumption. However, it is unclear whether ADH1B*2 modifies the relationship between moderate alcohol consumption and severity of NAFLD.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
In this study, we show that perforin can act as an immune regulator to prevent the progression of NAFLD. Aged perforin-deficient (Prf−/−) mice have increased lipid accumulation in the liver compared to WT mice. With high-fat diet (HFD) challenge, Prf−/− mice have increased liver weight, more severe liver damage, and increased liver inflammation when compared with WT controls. Mechanistic studies revealed that perforin specifically regulates intrinsic IFN-γ production in CD4 T cells, not CD8 T cells. We found that CD4 T cell depletion reduces liver injury and ameliorates the inflammation and me...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Lee BW, Lee YH, Park CY, Rhee EJ, Lee WY, Kim NH, Choi KM, Park KG, Choi YK, Cha BS, Lee DH, Korean Diabetes Association (KDA) Fatty Liver Research Group Abstract This clinical practice position statement, a product of the Fatty Liver Research Group of the Korean Diabetes Association, proposes recommendations for the diagnosis, progression and/or severity assessment, management, and follow-up of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Patients with both T2DM and NAFLD have an increased risk of non-alcoholic steatohepatitis (NASH) and fibrosis and a higher...
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Authors: Khneizer G, Rizvi S, Gawrieh S Abstract Nonalcoholic fatty liver disease (NAFLD) has emerged as the leading liver disease globally. NAFLD patients can have a progressive phenotype, non-alcoholic steatohepatitis (NASH) that could lead to cirrhosis, liver failure and cancer. There is a close bi-directional relationship between NAFLD and type 2 diabetes mellitus (T2DM); NAFLD increases the risk for T2DM and its complications whereas T2DM increases the severity of NAFLD and its complications. The large global impact of NAFLD and T2DM on healthcare systems requires a paradigm shift from specialty care to early ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Abstract The most common cause of liver disease worldwide is now non-alcoholic fatty liver disease (NAFLD). NAFLD refers to a spectrum of disease ranging from steatosis to non-alcoholic steatohepatitis, causing cirrhosis, and ultimately hepatocellular carcinoma. However, the impact of NAFLD is not limited to the liver. NAFLD has extra-hepatic consequences, most notably, cardiovascular and renal disease. NAFLD and chronic kidney disease share pathogenic mechanisms including insulin resistance, lipotoxicity, inflammation and oxidative stress. Not surprisingly, there has been a recent surge in efforts to manage NAFLD...
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
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