Peripheral neuropathies in rheumatic diseases: More diverse and frequent than expected. A cross ‐sectional study
ConclusionPN has variable distribution and high frequency in patients with RD; NQ+ increases the risk of presenting NCS+ for PN.
Publication date: Available online 26 February 2020Source: Current Therapeutic ResearchAuthor(s): Patrice Vincent, Thibaut Lucas de Couville, Thierry Thomas
ConclusionsThe association of rs4867568 and rs143383 with KOA was successfully replicated in the Chinese Han population. Moreover, rs4867568 was found significantly associated with the severity of KOA. More studies are warranted to explore the functional role of rs4867568 in the development of KOA.Key Points• A novel variant near Lsp1p3 is associated with knee osteoarthritis.• Baseline characteristics of the subjects.• Comparison of the genotype and allele frequency of the Lsp1p3, GDF5, and FTO.• Association of the Lsp1p3, GDF5, and FTO with KOA severity.
Publication date: Available online 25 February 2020Source: European Journal of Integrative MedicineAuthor(s): Mitra Abbasifard, Rahele Zareshahi
In this study, 11 circRNAs (hsa_circ_0000479, hsa_circ_0002316, hsa_circ_0000317, hsa_circ_0082688, hsa_circ_0082689, hsa_circ_0087798, hsa_circ_0008529, hsa_circ_0000787, hsa_circ_0021727, hsa_circ_0000175, and hsa_circ_0003694) which were found to be significantly up-regulated in both peripheral blood mononuclear cells (PBMCs) from SLE patients in our previous study, and T cells from SLE patients in previous literature, were chosen for validation by quantitative reverse transcription-polymerase chain reaction in PBMCs from 50 new-onset SLE patients, 24 new-onset rheumatoid arthritis (RA) patients, 24 new-onset ankylosing...
Conditions: Rotator Cuff Tear Arthropathy; Shoulder Osteoarthritis Intervention: Behavioral: Patient-led rehab with short immobilization Sponsors: University of Missouri-Columbia; Harry S. Truman Memorial Veterans Hospital Not yet recruiting
Condition: Rheumatoid Arthritis Intervention: Other: Quantitative ATX and LPA determination in plasma and sputum Sponsor: Hospices Civils de Lyon Not yet recruiting
ConclusionAll results showed the protective effects of the dominant model of COX ‐2 rs2745557 polymorphism and risk factor of 15‐PGDH rs8752 polymorphism on SLE development.
Abstract The sum of squared score (SSU) and sequence kernel association test (SKAT) are the two good alternative tests for genetic association studies in case-control data. Both SSU and SKAT are derived through assuming a dose-response model between the risk of disease and genotypes. However, in practice, the real genetic mode of inheritance is impossible to know. Thus, these two tests might losepower substantially as shown in simulation results when the genetic model is misspecified. Here, to make both the tests suitable in broad situations, we propose two-phase SSU (tpSSU) and two-phase SKAT (tpSKAT), where the ...
CONCLUSION: Opioids are commonly dispensed in the ED for SLE patients. This is true even for patients utilizing the ED for SLE-related disease activity/complications. PMID: 32091614 [PubMed - as supplied by publisher]
OBJECTIVE: Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are associated with mental illness. The risk of serious mental illness, including deliberate self-harm (DSH), in these conditions is not well known. We aimed to determine if RA or AS inde...