Biosynthesis of pyranonaphthoquinone polyketides reveals diverse strategies for enzymatic carbon-carbon bond formation.

Biosynthesis of pyranonaphthoquinone polyketides reveals diverse strategies for enzymatic carbon-carbon bond formation.
Curr Opin Chem Biol. 2013 Jul 22;
Authors: Metsä-Ketelä M, Oja T, Taguchi T, Okamoto S, Ichinose K
Abstract
Pyranonaphthoquinones synthesized by Streptomyces bacteria via type II polyketide pathways are aromatic compounds build around a common three-ring structure, which is composed of pyran, quinone and benzene rings. Over the years, actinorhodin in particular has served as a model compound for studying the biosynthesis of aromatic polyketides, while some of the other metabolites such as granaticin, medermycin, frenolicin and alnumycin A have enabled comparative studies that complement our understanding how these complex biological systems function and have evolved. In addition, despite the similarity of the aglycone units, pyranonaphthoquinones in effect display remarkable diversity in tailoring reactions, which include numerous enzymatic carbon-carbon bond forming reactions. This review focuses on the current status of molecular genetic, biochemical and structural investigations on this intriguing family of natural products.
PMID: 23886982 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - July 22, 2013 Category: Biochemistry Authors: Metsä-Ketelä M, Oja T, Taguchi T, Okamoto S, Ichinose K Tags: Curr Opin Chem Biol Source Type: research