Clinical outcomes following injections of leukocyte-rich platelet-rich plasma in osteoarthritis patients

This study aimed to investigate the efficacy of multiple injections of LR-PRP for the treatment of KOA and determine an LR-PRP treatment protocol for KOA in actual clinical practice.HypothesisWe hypothesized that using abundant LR-PRP would improve outcomes in patients with KOA.Study DesignProspective, cross-sectional, interventional, randomized trial.MethodsIntra-articular LR-PRP injections were administered to 50 knees. Patients received six injections of LR-PRP in total, which were administered at 4-week intervals. Patients were evaluated based on clinical outcomes, including visual analog scale (VAS) scores, Knee injury and Osteoarthritis Outcome Scores (KOOS), and magnetic resonance images (MRI) and radiographic findings before treatment and at 3 and 6 months after treatment. We investigated the recurrence of pain and presence/absence of MRI changes. Furthermore, we examined the Outcome Measures In Rheumatology-Osteoarthritis Research Society International (OMERACT-OARSI) responder criteria.ResultsThe mean improvement rate, as assessed by VAS, was 61.6% (P
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research

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Link N suppresses interleukin-1β-induced biological effects on human osteoarthritic cartilage. Eur Cell Mater. 2020 Jan 15;39:65-76 Authors: Alaqeel M, Grant MP, Epure LM, Salem O, AlShaer A, Huk OL, Bergeron SG, Zukor DJ, Kc R, Im HJ, Anbazhagan AN, Antoniou J, Mwale F Abstract Osteoarthritis (OA) is a disease of diarthrodial joints associated with extracellular matrix proteolytic degradation under inflammatory conditions, pain and disability. Currently, there is no therapy to prevent, reverse or modulate the disease course. The present study aimed at evaluating the regenerative potential of Link...
Source: European Cells and Materials - Category: Cytology Tags: Eur Cell Mater Source Type: research
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Source: Journal of Back and Musculoskeletal Rehabilitation - Category: Orthopaedics Tags: J Back Musculoskelet Rehabil Source Type: research
n E Abstract The role of the patella is paramount in the transmission of the quadriceps muscle forces, the increase of the lever arm, the distribution of the forces on the trochlea and the centring of the extensor apparatus. Despite the low incidence of patellar factures in comparison with other lower limb fractures, the painful and functional complications, such as knee stiffness, loss of extension and patellofemoral osteoarthritis, can be very disabling and will often compromise the return to a professional or recreational activity and induce falls in the elderly population. Treatment can be conservative or surg...
Source: Swiss Medical Weekly - Category: General Medicine Authors: Tags: Swiss Med Wkly Source Type: research
a Cruz Diane Liu Eduardo Bruera Palliative care is seeing cancer patients earlier in the disease trajectory with a multitude of chronic issues. Chronic non-malignant pain (CNMP) in cancer patients is under-studied. In this prospective study, we examined the prevalence and management of CNMP in cancer patients seen at our supportive care clinic for consultation. We systematically characterized each pain type with the Brief Pain Inventory (BPI) and documented current treatments. The attending physician made the pain diagnoses according to the International Association for the Study of Pain (IASP) task force classific...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
In highly active older individuals, end-stage ankle osteoarthritis has traditionally been treated using tibiotalar arthrodesis, which provides considerable pain relief. However, there is a loss of ankle joint ...
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Research article Source Type: research
Endocannabinoids are showing great promise as effective mediators for controlling joint inflammation and pain. One strategy that could be harnessed to promote endogenous cannabinoid function is to inhibit the ...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
ConclusionThe proposed end-to-end fully automatic model which is computationally efficient has the potential to achieve the real automatic diagnosis of knee OA and be used as computer-aided diagnosis tools in clinical applications.
Source: International Journal of Computer Assisted Radiology and Surgery - Category: Intensive Care Source Type: research
This study will provide high-quality evidence to assess whether krill oil 2  g/day reduces pain and effusion-synovitis size in older adults with clinical knee OA and knee effusion-synovitis. If krill oil is effective and confirmed to be safe, we will provide compelling evidence that krill oil improves pain and function, changes disease trajectory and slows disease progres sion in OA. Given the lack ofapproved therapies for slowing disease progression in OA, and moderate cost of krill oil, these findings will be readily translated into clinical practice.Trial registrationAustralian New Zealand Clinical Trials Registr...
Source: Trials - Category: Research Source Type: clinical trials
Condition:   Osteoarthritis, Knee Interventions:   Drug: Duloxetine;   Drug: Placebo oral tablet Sponsors:   Kristian Kjær Petersen;   CCBR, Aalborg;   Aalborg University Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Current Epidemiology Reports - Category: Epidemiology Source Type: research
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