Long-term impact of an educational antimicrobial stewardship programme in primary care on infections caused by extended-spectrum β-lactamase-producing Escherichia coli in the community: an interrupted time-series analysis

Spanish study reported that an antibiotic stewardship intervention in 214 primary care clinics (serving 2 million patients), had a moderate effect on inappropriate antibiotic use, from 1794 (36.5%) inappropriate instance identified in 2014 to 1793 (26.9%) in 6665 in 2017.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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The CDC is reporting cases of an E. coli outbreak linked to romaine lettuce in 23 states. They were grown in or near Salinas, California. The number of people sick has increased from 67 to 102 in one week. Anna Werner reports.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
Abstract Condensation of rhodanine (1) with pyrazol-3(2H)-one derivatives (2a-f) gave 5-substituted-2-thioxo-1,3-thiazolidin-4-one derivatives (3a-f). Reaction of compound (1) with 2-arylmethylidene-malononitrile (4a-d) yielded the unexpected derivatives (5a-d). The latter compounds were subjected to cyclization reactions with malononitrile under different basic conditions, hydroxylamine hydrochloride and/or thiourea to furnish the fused thiazole derivatives (6a-d) and (8-10a-d). Coupling of (1) with diazotized aromatic amines (11a-c) in pyridine afforded the arylhydrazones (12a-c). Fusion of latter compounds with...
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research
Authors: Bagai S, Prakash A, Agrawal A Abstract Aim: To determine the proportion of patients who have Acute Kidney Injury (AKI), identify severity of AKI using RIFLE criteria and to identify associated factors with AKI. Methods: One thousand consecutive medical in-patients were screened for AKI and severity assessed using RIFLE criteria in tertiary care hospital in Northern India. Patients with medical renal disease and obstructive uropathy were excluded. Serum creatinine of all patients were done on days 0, 3, 7 and 14. CKD cases were also excluded. AKI patients were followed at 4 weeks and 3 months. Resul...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Publication date: February 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 186Author(s): Serge Kliewer, Sebastian G. Wicha, Astrid Bröker, Tim Naundorf, Tugba Catmadim, Eva Katharina Oellingrath, Marcus Rohnke, Wolfgang R. Streit, Christel Vollstedt, Helmut Kipphardt, Wolfgang MaisonAbstractPolyethylene (PE) foils were modified with potent contact-active antibacterial quaternary ammonium salts (QAS) by an atmospheric air plasma activation step, followed by graft-polymerisation of vinylbenzyltrimethylammonium chloride (VBTAC) monomers. The presented approach uses a cost efficient air plasma activation and su...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 21 November 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Yan He, Yue Zhang, Madi Sun, Chao Yang, Xiao Zheng, Chengxin Shi, Zhimin Chang, Zheng Wang, Jinying Chen, Shuchen Pei, Wen-fei Dong, Dan Shao, Junjun SheAbstractChlorhexidine (CHX) is a widely used antiseptic in various infection control practices. In this work, we have developed biodegradable mesoporous organosilica nanoparticles (MONs) through a one-pot synthesis by employing CHX as a bifunctional agent that not any acts as a cationic template to form the structure of mesopores but also serves as a broad-spectrum a...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 3 December 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Rajasree Shanmuganathan, Felix LewisOscar, Sabarathinam Shanmugam, Nooruddin Thajuddin, Sulaiman Ali Alharbi, Naiyf S. Alharbi, Kathirvel Brindhadevi, Arivalagan PugazhendhiAbstractBacterial pathogenicity is becoming a major cause of morbidity and mortality around the globe. Researchers are tirelessly finding solutions to cure or prevent infections caused by bacterial pathogens. Nanotechnology is a fast-growing area of research, effectively influencing and preventing bacterial growth. Nanoparticles (NPs...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
By SAURABH JHA, MD Slumdog TB No one knows who gave Rahul Roy tuberculosis. Roy’s charmed life as a successful trader involved traveling in his Mercedes C class between his apartment on the plush Nepean Sea Road in South Mumbai and offices in Bombay Stock Exchange. He cared little for Mumbai’s weather. He seldom rolled down his car windows – his ambient atmosphere, optimized for his comfort, rarely changed. Historically TB, or “consumption” as it was known, was a Bohemian malady; the chronic suffering produced a rhapsody which produced fine art. TB was fashionable in Victorian Britain...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Artificial Intelligence Health Tech Saurabh Jha TB tuberculosis Source Type: blogs
Fluoroquinolones are used to treat serious bacterial infections, including those caused by Escherichia coli and Salmonella enterica. The emergence of plasmid-mediated quinolone resistance (PMQR) represent a new challenge to the successful treatment of Gram-negative infections. As part of a long-term strategy to generate a reference database of closed plasmids from antimicrobial resistant foodborne bacteria, we performed long-read sequencing of 11 E. coli isolates from retail meats that were non-susceptible to ciprofloxacin. Each of the isolates had PMQR genes, including qnrA1, qnrS1, and qnrB19. The four qnrB19 genes were ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Publication date: 15 February 2020Source: Materials Chemistry and Physics, Volume 242Author(s): A.S. Rajashekharaiah, G.P. Darshan, H.B. Premkumar, P. Lalitha, S.C. Sharma, H. NagabhushanaAbstractNano biotechnology is rapidly growing eco-friendly research area and used in various broad sections, such as biology, chemistry, physics, biomedicine and material engineering. The synthesis of highly efficient, non-toxic, inexpensive and environmental friendly nanomaterial is an urgent need. The aim of the present work was assessment of anti-oxidant, anti-bacterial and cytotoxicity potentials of Bi2Zr2O7:Dy3+ (1–11 mol ...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
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