Not Stayin' Alive

This is not new news, but it's strong confirmation of earlier observations that have been somewhat controversial, and also bad news that the trend is continuing.That trend is declining life expectancy in the U.S. I'm not linking to the full report in JAMA because it's incredibly wonky and behind a paywall anyway, but rather to the associated editorial, which tells you what you need to know.Before we get into the substance of this, let me explain the concept of life expectancy. I'll try to put this simply, but some people find it confusing. It's really a fictitious, though useful, construct. It isn't really a prediction of the future, but it tells us something about the present. Below is a portion of what's called a " life table. " It shows the proportion of people in the U.S. who died in each 1-year age cohort in 2015.As you can see, .006383, or a little more than 6/1,000 male babies died before their first birthday. (A simplifying assumption is that all deaths occur on June 30. Don't worry about it.) Of the remaining male babies, .000453, which only 4/5 out of 10,000, died before their second birthday. So it's somewhat dangerous to be an infant but once you get past that you're in pretty good shape until you get old. It isn't until age 81 that the probability of death for men goes up to the same level as the infant mortality rate.So life expectancy at birth is the average (mean) age you would live if you were born in 2015 and experience the same probability of deat...
Source: Stayin' Alive - Category: American Health Source Type: blogs

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ConclusionSubstantial agreement exists among experts regarding many strong recommendations for the improvement of practice concerning the use of muscle relaxants and reversal agents during anaesthesia. In particular, the French Society of Anaesthesia and Intensive Care (SFAR) recommends the use of a device to monitor neuromuscular blockade throughout anaesthesia.
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
ConclusionsStudents with ID are at increased risk of developing depressive symptoms when exposed to negative social relationships (i.e., peer victimization or TSR conflict). For these students, the benefits of TSR warmth were far less important than the consequences of conflict.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Conclusions: Aside from ROM preservation at both C2-7 and TDR levels, COR restoration from ventrocranial location close to normal coordinates by posterior and inferior shifts was marked as a clinical success after MCTDR. The COR position along the x-axis after MCTDR was an important factor to determine maintenance of C2-7 ROM. PMID: 31940714 [PubMed - as supplied by publisher]
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
Conclusions: Our evidence suggests that the L5-KAL can serve as an indicator of the thoracic curve change in Scheuermann's disease and postural kyphosis patients and should be considered in clinical practice. PMID: 31940713 [PubMed - as supplied by publisher]
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
Publication date: Available online 16 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Victoria S. Marshe, Farhana Islam, Malgorzata Maciukiewicz, Laura M. Fiori, Volodymyr Yerko, Jennie Yang, Gustavo Turecki, Jane A. Foster, Sidney H. Kennedy, Daniel M. Blumberger, Jordan F. Karp, James L. Kennedy, Benoit H. Mulsant, Charles F. Reynolds, Eric J. Lenze, Daniel J. MüllerAbstractBackgroundMicroRNAs (miRNAs) are small 22 nucleotides long, non-coding RNAs that are potential biomarkers for antidepressant treatment response. We aimed to replicate previous associations of miRNAs wi...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
ConclusionsDue to its pro-cognitive effects and faster antidepressant effect, serial ketamine administration might be a more favorable short-term treatment option than ECT.LimitationsAs this research employed a naturalistic study design, patients were not systematically randomized, there was no control group and patients received concurrent and partially changing medications during treatment.Clinical trials registrationFunctional and Metabolic Changes in the Course of Antidepressive Treatment, https://clinicaltrials.gov/ct2/show/NCT02099630, NCT02099630.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
CONCLUSIONS The results of this prospective study confirm that the Group 1 having undergone the 6-weeek long combined symptomatic non-operative therapy of GPS proposed by us showed a statistically significant improvement in all the parameters assessed by HAGOS and these values showed no statistically significant difference from those of the Control Group of healthy individuals. Key words: Groin Pain Syndrome (GPS), professional football player, HAGOS (Copenhagen Hip and Groin Outcome), symptomatic therapy. PMID: 31941572 [PubMed - in process]
Source: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca - Category: Orthopaedics Tags: Acta Chir Orthop Traumatol Cech Source Type: research
Authors: Štulík J, Huvar P, Nesnídal P Abstract PURPOSE OF THE STUDY Atlantoaxial Rotatory Dislocation (AARD) mostly occurs in children and prevailing majority of cases are successfully managed by non-operative treatment. Surgical intervention is necessary in patients in whom non-operative treatment failed, in case of repeated dislocations and in patients with anatomical defects of the atlantoaxial complex. The purpose of the presented study is the radiological and clinical evaluation of patients with AARD surgically treated at our department. MATERIAL AND METHODS In the period from 2001 to 201...
Source: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca - Category: Orthopaedics Tags: Acta Chir Orthop Traumatol Cech Source Type: research
Publication date: Available online 17 January 2020Source: Neuroscience ResearchAuthor(s): Zhaofa Wu, Yulong LiAbstractPurinergic transmitters such as adenosine, ADP, ATP, UTP, and UDP-glucose play important roles in a wide range of physiological processes, including the sleep-wake cycle, learning and memory, cardiovascular function, and the immune response. Moreover, impaired purinergic signaling has been implicated in various pathological conditions such as pain, migraine, epilepsy, and drug addiction. Examining the function of purinergic transmission in both health and disease requires direct, sensitive, non-invasive too...
Source: Neuroscience Research - Category: Neuroscience Source Type: research
ConclusionApplication of HFSCS provides an effective treatment for SNI-induced persistent mechanical hyperalgesia by attenuating ERK, JNK, and p38 activation in the dorsal root ganglia and the spinal dorsal horn.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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