New borrelidins from Onchidium sp. associated StreptomycesolivaceusSCSIO LO13.

New borrelidins from Onchidium sp. associated StreptomycesolivaceusSCSIO LO13.
Chem Biodivers. 2019 Nov 26;:
Authors: Zhou Z, Wu Q, Xie Q, Zhang H, Sun C, Ju J
Abstract
Borrelidins M-O (1-3), along with four previously known family members (4-7), were isolated from marine pulmonated mollusks Onchidium sp. associated Streptomyces olivaceus SCSIO LO13. The structures of 1-3 were elucidated by extensive spectral analyses of HRESIMS, 1D and 2D NMR datasets. In addition, the cytotoxic and antibacterial activities of 1-7 were evaluated enabling us to propose some tentative structure-activity relationships (SARs), especially those involving modifications at C(22) and the moieties at C(7), C(8) of the borrelidin scaffold.
PMID: 31769919 [PubMed - as supplied by publisher]

Source: Chemistry and Biodiversity - November 25, 2019 Category: Biochemistry Authors: Zhou Z, Wu Q, Xie Q, Zhang H, Sun C, Ju J Tags: Chem Biodivers Source Type: research