A titanic drug resistance threat in Cryptococcus neoformans.

A titanic drug resistance threat in Cryptococcus neoformans. Curr Opin Microbiol. 2019 Nov 22;52:158-164 Authors: Zafar H, Altamirano S, Ballou ER, Nielsen K Abstract Increasing resistance to frontline antifungals is a growing threat to global health. In the face of high rates of relapse for patients with cryptococcal meningitis and frequent drug resistance in clinical isolates, recent insights into Cryptococcus neoformans morphogenesis and genome plasticity take on new and urgent meaning. Here we review the state of the understanding of mechanisms of drug resistance in the context of host-relevant changes in Cryptococcus morphology and cell ploidy. PMID: 31765991 [PubMed - as supplied by publisher]
Source: Current Opinion in Microbiology - Category: Microbiology Authors: Tags: Curr Opin Microbiol Source Type: research

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