Interrater Reliability of the Modified Ashworth Scale with Standardized Movement Speeds: A Pilot Study.

Conclusion: Using consistent movement velocity, novice evaluators were able to score spasticity with reasonable interrater reliability when assessing the wrist flexors but not the ankle plantar flexors. PMID: 31762545 [PubMed]
Source: Physiotherapy Canada - Category: Physiotherapy Authors: Tags: Physiother Can Source Type: research

Related Links:

             Basel, 23 January 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced positive topline results from the pivotal Part 2 of the FIREFISH study, evaluating risdiplam in infants aged 1-7 months with Type 1 spinal muscular atrophy (SMA). The primary outcome measure of the study was the proportion of infants sitting without support for at least five seconds at 12-months of treatment, assessed by the Gross Motor Scale of the Bayley Scales of Infant and Toddler Development Third Edition (BSID-III). Safety for risdiplam in the FIREFISH study was con...
Source: Roche Investor Update - Category: Pharmaceuticals Source Type: news
Conclusion: The recruitment/derecruitment was successfully tracked by the algorithm. Because of its parallel structure, this algorithm can be efficiently accelerated, which lays the basis for its real-time applications in human–machine interfaces. Significance: The proposed method substantially broadens the domains of applicability of the algorithm.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Spinal muscular atrophy (SMA) is typically characterized as a motor neuron disease. Untreated patients with the most severe form, SMA Type 1, die early with infantile-onset progressive skeletal, bulbar, and respiratory muscle weakness. Such patients are now living longer due to new disease-modifying treatments such as gene replacement therapy (onasemnogene abeparvovec) approved by FDA very recently and nusinersen, a central nervous system (CNS)-directed treatment, which became FDA-approved only 3 years ago.
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research
ConclusionsBulbar onset was a significant risk predictor for survival. Slower disease progression correlated with better outcomes. Age of onset may differ among ethnic groups. Male patients are more likely to develop Amyotrophic Lateral Sclerosis (ALS) and have shorter survival duration.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Authors: Kassubek J, Müller HP Abstract Introduction: In the last decade, multiparametric magnetic resonance imaging (MRI) has achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to increase the understanding of the associated pathophysiology. The aim of this review is to summarize recent progress in the development of MRI-based techniques aiming to support the clinical diagnosis in ALS.Areas covered: The review of structural and functional MRI applications to ALS and its variants (restricted phenotypes) is focused on the potential of MRI techniques which contribute to the diagnost...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Abstract Sacral reflexes are important to allow the SCI practitioner to gain information about the state of the sacral spinal cord segments. The presence of the bulbocavernosus and/or the anal wink reflex indicate an intact spinal reflex arc and reflex conal autonomic function (as part of the upper motor neuron syndrome); their absence defines a lower motor neuron syndrome. The assessment of sacral reflexes helps predict the type of bladder, bowel and sexual functions and the related therapeutic interventions. We suggest adding the sacral component of the International Standards for the Assessment of Autonomic Fun...
Source: Anal Sci - Category: Chemistry Authors: Tags: Spinal Cord Ser Cases Source Type: research
Abstract The examination of sacral reflexes provides an important method to differentiate an upper motor neuron vs lower motor neuron spinal cord injury (SCI). Two common sacral mediated reflexes used as part of the neurological assessment include the bulbocavernosus reflex (BCR) and anal reflex. As the clinical information from these tests are similar, we suggest that the anal reflex provides a better first option as a non-invasive clinical assessment of sacral reflex status in clinical practice in SCI as the testing for the anal reflex is less intrusive and already being performed as part of the International St...
Source: Anal Sci - Category: Chemistry Authors: Tags: Spinal Cord Ser Cases Source Type: research
The precise pattern of motor neuron (MN) activation is essential for the execution of motor actions; however, the molecular mechanisms that give rise to specific patterns of MN activity are largely unknown. Phrenic MNs integrate multiple inputs to mediate inspiratory activity during breathing and are constrained to fire in a pattern that drives efficient diaphragm contraction. We show that Hox5 transcription factors shape phrenic MN output by connecting phrenic MNs to inhibitory pre-motor neurons.Hox5 genes establish phrenic MN organization and dendritic topography through the regulation of phrenic-specific cell adhesion p...
Source: eLife - Category: Biomedical Science Tags: Neuroscience Source Type: research
Gitika Batra, Manav Jain, Rahul Soloman Singh, Amit Raj Sharma, Ashutosh Singh, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2019 51(6):418-425 Amyotrophic lateral sclerosis (ALS) is an untreatable and fatal neurodegenerative disease that is identified by the loss of motor neurons in the spinal cord, brain stem, and motor cortex which theatrically reduces life expectancy. Although the primary cause of ALS remains unclear, its heterogeneity put forward for consideration of association with various factors, including endogenous and/or environmental ones, which may be involved in progressive motor neuron stress t...
Source: Indian Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
A major study will assess if new - and existing - drugs can help people with motor neurone disease.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
More News: Botox | Brain | Canada Health | Motor Neurone Disease | Neurology | Physical Therapy | Physiotherapy | Rehabilitation | Students | Study | Universities & Medical Training