Arsenic exposure: A public health problem leading to several cancers.
Arsenic exposure: A public health problem leading to several cancers. Regul Toxicol Pharmacol. 2019 Nov 22;:104539 Authors: Palma-Lara I, Martínez-Castillo M, Quintana-Pérez JC, Arellano-Mendoza MG, Tamay-Cach F, Valenzuela-Limón OL, García-Montalvo EA, Hernández-Zavala A Abstract Arsenic, a metalloid and naturally occurring element, is one of the most abundant elements in the earth's crust. Water is contaminated by arsenic through natural sources (underground water, minerals and geothermal processes) and anthropogenic sources such as mining, industrial processes, and the production and use of pesticides. Humans are exposed to arsenic mainly by drinking contaminated water, and secondarily through inhalation and skin contact. Arsenic exposure is associated with the development of vascular disease, including stroke, ischemic heart disease and peripheral vascular disease. Also, arsenic increases the risk of tumors of bladder, lungs, kidneys and liver, according to the International Agency for Research on Cancer and the Food and Drug Administration. Once ingested, an estimated 70-90% of inorganic arsenic is absorbed by the gastrointestinal tract and widely distributed through the blood to different organs, primarily to the liver, kidneys, lungs and bladder and secondarily to muscle and nerve tissue. Arsenic accumulates in the organs, especially in the liver. Its excretion mostly takes place through urination. The toxicokine...
CONCLUSIONS: Our findings support the protective effect a normal weight against advanced adenomas. Reduction of BMI value should be pursued in healthy programs. PMID: 32233893 [PubMed - as supplied by publisher]
Conclusion: There is a slightly increasing trend in the occurrence of esophageal perforations. Contemporary treatment is less invasive with similar results. Patients treated in high-volume hospitals have better prognosis. PMID: 32233883 [PubMed - as supplied by publisher]
Publication date: May 2020Source: Epilepsy &Behavior, Volume 106Author(s): Laura Abraira, Nicola Giannini, Estevo Santamarina, Sonia Cazorla, Alejandro Bustamante, Manuel Quintana, Manuel Toledo, Laia Grau-López, Marta Jiménez, Jordi Ciurans, Juan Luis Becerra, Mónica Millán, Pere Cardona, Mikel Terceño, Josep Zaragoza, David Cánovas, Teresa Gasull, Xavier Ustrell, Marta Rubiera, Mar Castellanos
Publication date: Available online 2 April 2020Source: Brain StimulationAuthor(s): Qi Wang, Dai Zhang, Ying-Yu Zhao, Hong Hai, Yue-Wen Ma
More than one fifth of patients who are treated for gynecologic malignancies experience financial toxicity, results of a single-center study suggest.
Results of a systematic review and meta-analysis support a possible role for osimertinib in the management of non-small-cell lung cancer (NSCLC) patients with intracranial metastatic disease, researchers say.Reuters Health Information
Authors: Montemurro F, Nuzzolese I, Ponzone R Abstract Introduction: The administration of chemotherapy before (neoadjuvant), rather than after surgery (adjuvant) in early breast cancer has been considered an optional strategy for patients with operable breast cancer. We reviewed this concept considering recent results in the field.Areas covered: Herein, the authors cover neoadjuvant chemotherapy with or without biologics in triple-negative and HER2-positive operable breast cancer with a focus on rates of complete pathological remission (pCR) in the breast and axilla. The impact of the CREATE X and KATERINE randomi...
One of the biggest challenges of this unsettling time is the isolation we feel as we’re separated from friends and family, all the people for whom we care most deeply. But just being alone is only part of the difficulty. Our sense of remoteness is intensified by a pall of unease we can’t define: Loss and sorrow are also in the air. We fear losing—or we may have already lost—people we love. And when we work up the courage to look beyond our individual personal spheres, we see that many people who have made our world better, in big and small ways, have vanished before we were ready to let them go. But...
Publication date: Available online 2 April 2020Source: Saudi Pharmaceutical JournalAuthor(s): Md. Salman Akhtar, Naseem Akhter, Mohammad Zeeshan Najm, SVS Deo, NK Shukla, Shaia Saleh R. Almalki, Raed A. Alharbi, Abdulmajeed Abdulghani A. Sindi, Abdulmohsen Alruwetei, Abrar Ahmad, Syed Akhtar Husain
Dr Mark Kris discusses the profound effect that the wait time between cancer being diagnosed and treatment being initiated has on both patients and physicians.Medscape Oncology
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