Effect of Inhibition of Colony Stimulating Factor 1 Receptor on Choroidal Neovascularization in Mice

This study evaluated the effect of the colony stimulating factor-1 receptor (CSF-1R) inhibitor PLX5622 on experimental laser-induced CNV. A 98% reduction of retinal microglia cells was observed in the retina one week after initiation of PLX5622 treatment, preventing accumulation of macrophages within the laser site and leading to a reduction of leukocytes within the choroid after CNV induction.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research