Some Down syndrome problems reversed in mice
In a mouse model of Down syndrome, blocking a cellular pathway in brain cells improved learning and memory.
Publication date: December 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 12Author(s): Sarah Cohen, Michelle Z. Gurvitz, Virginie Beauséjour-Ladouceur, Patrick R. Lawler, Judith Therrien, Ariane J. MarelliAbstractAs life expectancy in patients with congenital heart disease (CHD) has improved, the risk for developing noncardiac morbidities is increasing in adult patients with CHD (ACHD). Among these noncardiac complications, malignancies significantly contribute to the disease burden of ACHD patients. Epidemiologic studies of cancer risk in CHD patients are challenging because they require large numbers...
Notice NOT-OD-20-020 from the NIH Guide for Grants and Contracts
Notice NOT-OD-20-021 from the NIH Guide for Grants and Contracts
To assess whether the location of 71 Down syndrome specialty care clinics in the US make them inaccessible to a considerable portion of the American population.
Epigenetic mechanisms provide an interface between environmental factors and the genome and are influential in various diseases. These mechanisms, including DNA methylation, influence the regulation of develop...
Nature Reviews Neurology, Published online: 04 December 2019; doi:10.1038/s41582-019-0298-6Integrated stress response mediates cognitive decline in Down syndrome
This article discusses a patient with Down syndrome and worsening plaque psoriasis who died of an acute myocardial infarction.
Publication date: January 2020Source: Research in Developmental Disabilities, Volume 96Author(s): Zachary Rossetti, Chung eun Lee, Meghan Burke, Sarah HallAbstractMost siblings of individuals with intellectual and developmental disabilities (IDD) report positive sibling relationships. However, extant research often only examines the perspective of the nondisabled sibling; it is unclear whether siblings with IDD report close sibling relationships. Thus, the aim of this study was to understand adult sibling relationships from the perspectives of both siblings with and without IDD. Using dyadic interviews, we examined the per...