Some Down syndrome problems reversed in mice

In a mouse model of Down syndrome, blocking a cellular pathway in brain cells improved learning and memory.
Source: NIH Research Matters from the National Institutes of Health (NIH) - Category: Consumer Health News Source Type: news

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Publication date: December 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 12Author(s): Sarah Cohen, Michelle Z. Gurvitz, Virginie Beauséjour-Ladouceur, Patrick R. Lawler, Judith Therrien, Ariane J. MarelliAbstractAs life expectancy in patients with congenital heart disease (CHD) has improved, the risk for developing noncardiac morbidities is increasing in adult patients with CHD (ACHD). Among these noncardiac complications, malignancies significantly contribute to the disease burden of ACHD patients. Epidemiologic studies of cancer risk in CHD patients are challenging because they require large numbers...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Notice NOT-OD-20-020 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Notice NOT-OD-20-021 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
To assess whether the location of 71 Down syndrome specialty care clinics in the US make them inaccessible to a considerable portion of the American population.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Articles Source Type: research
Epigenetic mechanisms provide an interface between environmental factors and the genome and are influential in various diseases. These mechanisms, including DNA methylation, influence the regulation of develop...
Source: Clinical Epigenetics - Category: Research Authors: Tags: Research Source Type: research
Nature Reviews Neurology, Published online: 04 December 2019; doi:10.1038/s41582-019-0298-6Integrated stress response mediates cognitive decline in Down syndrome
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
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Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
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Source: Journal of Intellectual and Developmental Disability - Category: Disability Authors: Source Type: research
This article discusses a patient with Down syndrome and worsening plaque psoriasis who died of an acute myocardial infarction.
Source: Journal of the American Academy of Physician Assistants - Category: Primary Care Tags: Case Report Source Type: research
Publication date: January 2020Source: Research in Developmental Disabilities, Volume 96Author(s): Zachary Rossetti, Chung eun Lee, Meghan Burke, Sarah HallAbstractMost siblings of individuals with intellectual and developmental disabilities (IDD) report positive sibling relationships. However, extant research often only examines the perspective of the nondisabled sibling; it is unclear whether siblings with IDD report close sibling relationships. Thus, the aim of this study was to understand adult sibling relationships from the perspectives of both siblings with and without IDD. Using dyadic interviews, we examined the per...
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
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