Some Down syndrome problems reversed in mice

In a mouse model of Down syndrome, blocking a cellular pathway in brain cells improved learning and memory.
Source: NIH Research Matters from the National Institutes of Health (NIH) - Category: Consumer Health News Source Type: news

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Authors: Perepitchka M, Galat Y, Beletsky IP, Iannaccone PM, Galat V Abstract Trisomy 21 (T21), known as Down syndrome (DS), is a widely studied chromosomal abnormality. Previous studies have shown that DS individuals have a unique cancer profile. While exhibiting low solid tumor prevalence, DS patients are at risk for hematologic cancers, such as acute megakaryocytic leukemia and acute lymphoblastic leukemia. We speculated that endothelial cells are active players in this clinical background. To this end, we hypothesized that impaired DS endothelial development and functionality, impacted by genome-wide T21 altera...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusions The use of SMOs led to improvements in activity level outcomes in family-selected participation goals.
Source: JPO Journal of Prosthetics and Orthotics - Category: Orthopaedics Tags: CME ARTICLES Source Type: research
Conclusions: Symptomatic neonates with COVID-19 had high rates of respiratory support requirements. High CRP levels or a greater PT should alert the physician to more severe disease.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
PET imaging could be a useful tool for diagnosis and treatment of idiopathic...Read more on AuntMinnie.comRelated Reading: FDG levels show link between Alzheimer's, Down syndrome SNMMI 2020: Image of the Year scans reveal 'super-agers' New tau PET tracer better targets source of Alzheimer's New PET technique visualizes early Alzheimer's disease PET tracer could more precisely diagnose Alzheimer's
Source: Headlines - Category: Radiology Source Type: news
Source: International Journal of Speech-Language Pathology - Category: Speech-Language Pathology Authors: Source Type: research
In this study, we investigated the detection rate of 22q11.2 copy number abnormalities in 2500 fetuses using single nucleotide polymorphism (SNP) array and determined the common abnormal ultrasound findings in fetuses carrying the 22q11.2 copy number abnormalities. The 22q11.2 copy number abnormalities were identified in 13 fetuses with cardiovascular malformations (6/13), kidney malformations (3/13), isolated ultrasound markers (3/13), or high-risk Down syndrome based on maternal serum screening (1/13). Approximately 0.5% (13/2500) of the fetuses harbored 22q11.2 copy number abnormalities. The most frequent ultrasound fin...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
The U.S. National Institutes of Health (NIH) has provided additional funding...Read more on AuntMinnie.comRelated Reading: MRI-trained CAD identifies cognitive impairment FDG levels show link between Alzheimer's, Down syndrome New tau PET tracer better targets source of Alzheimer's New PET technique visualizes early Alzheimer's disease PET tracer could more precisely diagnose Alzheimer's
Source: Headlines - Category: Radiology Source Type: news
Nature Reviews Rheumatology, Published online: 14 September 2020; doi:10.1038/s41584-020-00508-8Arthritis disease burden worse in children with Down syndrome
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research
So. I suppose we have some catching up to do.Schuyler and I are in Virginia. Where we live.Well, that's partially true. Schuyler lives here half the time, splitting her time from month to month with her mother, who now lives in Michigan. It's not complicated on paper, as divorce rarely is, but in practice it's probably going to be fraught with unforeseen peril, as divorce almost always is. I have Schuyler here with me for one more week, and then my month without her begins. I think we can all predict how well I'll take that, but there it is. The price of change. Perhaps it's the fee for exchanging the predictable ennui of ...
Source: Schuyler's Monster: The Blog - Category: Disability Authors: Source Type: blogs
AbstractDown syndrome (DS) is one of the most well-recognized genetic disorders. Persons with DS are known to have a variety of co-morbid medical problems, affecting nearly all organ systems. Improved healthcare interventions and research have allowed for increased life span of persons with DS, although disorders of the neurologic system remain underexplored. The purpose of this systematic review is to provide clinically pertinent information on the neurological phenotypes of frequently occurring or clinically relevant conditions. A retrospective review of MEDLINE, Scopus, and Pubmed were used to identify sources among sev...
Source: Journal of Neurology - Category: Neurology Source Type: research
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