Scientists STOP triple negative breast cancer's spread in animal tests

Scientists have long struggled to identify what fuels the growth of triple negative breast cancer, the most aggressive form. New UConn and Jax Laboratory research has found a new target.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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CONCLUSION: Available cervical and breast cancers screening services are not attuned to refugee women's views where this study focuses attention on the roles and practices of doctors in preventive health care for refugee women. Merging their perspectives with those of providers and policymaker's can fill the existing gaps and support to formulate the new interventions that will improve women's access to such preventative services. PMID: 31833117 [PubMed - as supplied by publisher]
Source: Health Promotion Journal of Australia - Category: International Medicine & Public Health Tags: Health Promot J Austr Source Type: research
Conclusion: MiR-7-5p suppresses NSCLC metastasis. Targeting miR-7-5p may contribute to the success of NSCLC therapy. PMID: 31832068 [PubMed - in process]
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Tags: Cell Mol Biol Lett Source Type: research
This study aimed to determine whether brevilin A has anti-melanoma effects, and whether STAT3 signaling is involved in the effects.Main methodsA mouse A375 xenograft model, as well as A375 and A2058 cell models were employed to assess the in vivo and in vitro anti-melanoma effects of brevilin A. A375 cells stably expressing STAT3C, a constitutively active STAT3 mutant, were used to determine the role of STAT3 signaling in brevilin A's anti-melanoma effects.Key findingsIntraperitoneal injection of brevilin A dose-dependently inhibited melanoma growth in mice and suppressed STAT3 phosphorylation in the tumors. In cultured ce...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 13 December 2019Source: Inorganica Chimica ActaAuthor(s): Sonja Ž. Đurić, Marija Mojicevic, Sandra Vojnovic, Hubert Wadepohl, Tina P. Andrejević, Nevena Lj. Stevanović, Jasmina Nikodinovic-Runic, Miloš I. Djuran, Biljana Đ. GlišićAbstractIn a continuing search for a novel metal-containing antimicrobial agents, the present study reports the synthesis, characterization and biological evaluation of two silver(I) complexes with 1,10-phenanthroline-based ligands, [Ag(1,10-phen)2]CF3COO.H2O (Ag1) and [Ag(CF3COO)(5,6-epoxy-1,10-phen)]2 (Ag2), 1,10-phen is 1,10-phenanthroline...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 14 December 2019Source: Inorganic Chemistry CommunicationsAuthor(s): Meenakshi Rana, Aditi Jain, Vibha Rani, Papia ChowdhuryAbstractNanomaterials have secured an enduring position as a promising contender for various biological applications. Quantum dot (QD) is one such example of nano sized semiconductor material having unique optical characteristics that makes it an ideal candidate to be used as imaging tool for today’s medical industry. In the present study, the L-Glutathione (L-GSH) capped L-GSH-CdSeS/ZnS core/shell QDs were applied to visualize MCF-7 human breast cancer cells. ...
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
Conclusion: According to these data, monitoring this class of toxicities is of primary importance to avoid hypertension worsening and, thus, the risk of major cardiovascular events. PMID: 31829045 [PubMed - as supplied by publisher]
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
In this study, the miR-86-5p was induced in breast cancer cells (MDA-MB-231) and the effect of miR-86-5p replacement on the expression level of VEGF, FOX, MMP3, SIRT1, and OLFM4 genes was investigated.Material and methodsThe miR-86-5p mature sequence was designed, synthesized and transfected into the MDA-MB-231 cells via jetPRIME® transfection reagent. The optimal concentration of miRNA was determined using qRT-PCR post-transfection. MTT assay was performed to evaluate the cell toxicity of miR-86-5p replacement. For finding the role of miR-86-5p in apoptosis, the annexin V/Propidium iodid (PI) assay was performed by fl...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Authors: Kereama-Royal I, Jones S, Wijohn EL, Doole C, Burgess EL, Came H Abstract Māori women with advanced breast cancer are less than half as likely as their Pākehā counterparts to reach the five-year survival mark. We argue that this inequity is unacceptable. We trace the inequity back to i) inadequate screening and risk assessment, ii) lack of support for patient navigation, iii) failure to offer accessible state-of-the-art treatments, and iv) delays in receiving life-prolonging care. We posit that each of these factors is a site of institutional racism and privilege as they cause Māori women to experience...
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
ConclusionsThe predictive efficiency and accuracy of the scoring system were acceptable, and the system could be used to predict and screen groups at high risk for breast cancer-related lymphedema.
Source: International Journal of Nursing Sciences - Category: Nursing Source Type: research
Authors: Zhang M, Wang L, Liu Q, Zhong X, Wang Z, Tian Z PMID: 31833732 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
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