Alternative Effective and Safe Induction Regimens for Newly Diagnosed Acute Myeloid Leukemia in Patients with Cardiac Contra-indication to Anthracyclines

There is no consensual regimen for AML patients with contra-indication to receive anthracyclines (because of cardiac dysfunction or prior exposure to anthracyclines). Our study compared 3 anthracycline-free regimens currently used in France. It showed that, despite the poor outcome of these patients, Topotecan plus Cytarabine is effective and safe in these patients.

Source: Clinical Lymphoma, Myeloma and Leukemia - November 25, 2019 Category: Hematology Authors: Clemence Marcault, Geoffroy Venton, Lauris Gastaud, Lionel Mannone, Jerome Rey, Evelyne D'Incan, Colombe Saillard, Aude Charbonnier, Sophie Raynaud, Norbert Vey, Thomas Cluzeau Tags: Original Study Source Type: research