miR-488-5p and its role in melanoma.

This study showed the involvement of miR-488-5p in Wnt/β-catenin pathway and the function as tumor suppressor. Transfection of miR-488-5p mimic led to inhibition of proliferation, migration, anchorage independent growth and led to induction of apoptosis. These data indicated that miR-488-5p acts as a tumor suppressor and is lost during melanoma development which has influence on proliferation and migration. The loss of miR-488-5p was confirmed in vivo by in situ hybridization on melanoma tissue. PMID: 31765608 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - Category: Pathology Authors: Tags: Exp Mol Pathol Source Type: research