Viral Hemorrhagic Fevers in Pregnant Women and the Vaccine Landscape: Comparisons Between Yellow Fever, Ebola, and Lassa Fever

AbstractPurpose of ReviewAs research efforts have advanced to understand the pathophysiology of viral hemorrhagic fevers (VHF) and other epidemic viral infections and develop medical countermeasures such as vaccines, pregnant women have remained an underexamined subgroup. To better understand the implications of future outbreaks of VHF for pregnant women amidst an evolving vaccine landscape, we examine three pathogens —yellow fever, Ebola, and Lassa fever—each with different levels of evidence and understanding of disease in pregnancy and at varying stages of vaccine development.Recent FindingsThere are very limited data available on yellow fever disease in pregnancy and the current live-attenuated 17D yellow fever vaccine is recommended for pregnant women at high risk of exposure. Evidence on Ebola virus disease in pregnancy shows very high case fatality rates (CFRs) among pregnant women and their infants, with mixed evidence on whether mortality is higher in pregnant women than non-pregnant adults. The replication-competent rVSV-ZEBOV vaccine is currently being offered to at-risk pregnant women in the Democratic Republic of the Congo after a revision to an earlier protocol that excluded them. For Lassa fever, there is evidence that CFR is higher in pregnant individuals than non-pregnant adults, especially later in gestation, with high rates of fetal or perinatal loss associated with infection. There are currently no Lassa fever vaccine candidates that have been ...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research

Related Links:

Authors: Fournier E Abstract Carpal tunnel syndrome (CTS) is too common a condition not to daily interact with the practitioner, if only because of its entanglement to other pathologies, causal or chance association. The typical symptomatology, with hand paresthesia and morning pain upon waking, is related to a median nerve injury in the confined space of the carpal tunnel, more often by local inflammation and tenosynovitis of the finger flexors (repetitive activity of the hands). SCC may be secondary to situations (pregnancy) or conditions (edema, hypothyroidism…), which exaggerate the ordinary pathophysiol...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Authors: Cerveró A, Sedano-Tous MJ, Madera J, López-de-Eguileta A, Casado A Abstract The case concerns a 26-year-old patient with bilateral recurrent optic neuritis episodes in the context of suspected neuromyelitis optica. In the first outbreak, she had greatly impaired visual acuity of the left eye, as well as seeing ganglion cell layer damage in both eyes in the optic coherence tomography, with evidence of a possible extensive lesion in the optic chiasma. Likewise, MRI with contrast showed a great involvement of the left optic nerve that compromises the chiasma increasing the suspicion of a neuromy...
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
With Chinese authorities warning the coronavirus outbreak is accelerating, placing millions of people in more than a dozen Chinese cities under intense travel restrictions might seem like a good idea.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
The number of dead climbed to at least 80, while in the United States, five cases were confirmed.
Source: NYT Health - Category: Consumer Health News Authors: Tags: China Coronavirus (2019-nCoV) Medicine and Health Deaths (Fatalities) Politics and Government Travel and Vacations Lunar New Year Epidemics Viruses Airlifts Hubei Province (China) Wuhan (China) Source Type: news
Residents of China's Hubei province, where the new coronavirus outbreak was first reported, will be banned from entering Hong Kong from Monday as China tries to halt the rapid spread of the outbreak.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
.
Source: Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
AbstractPurpose of ReviewThe widespread incidence of morbidity and mortality associated with opioid use disorder (OUD) has resulted in a national crisis. One component of this public health epidemic includes a lack of an adequately trained healthcare workforce to provide opioid case management, prescribing, and dispensing. The Extension for Community Healthcare Outcomes (Project ECHO) is a tele-mentoring, guided practice model, which provides knowledge exchange from specialists and subspecialists to enable primary care providers and clinicians to deliver best practice care for complex health conditions like OUD. Project EC...
Source: Current Treatment Options in Psychiatry - Category: Psychiatry Source Type: research
UK government urged to reassure public that NHS is ready for cases within daysAbout 100,000 people could be infected with the new coronavirus around the world, experts have warned, as the UK government faced calls to reassure people that the NHS is ready to deal with any British cases within days.Prof Neil Ferguson, a public health expert at Imperial College, said his “best guess” was that there were 100,000 affected by the virus even though there are only 2,000 confirmed cases so far, mostly in the city of Wuhan in Chinawhere the virus first appeared.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak China Asia Pacific Science Source Type: news
France said on Sunday it expected to evacuate hundreds of its citizens from the Wuhan area in China, the epicentre of a coronavirus outbreak.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
In a rare sign of public discontent with the government, Chinese social media users are venting their anger at the government, after officials from Hubei province, where the coronavirus outbreak began, briefed the media on Sunday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
More News: Clinical Trials | Congo Health | Ebola | Ebola Vaccine | Epidemics | Epidemiology | Lassa Fever | Outbreaks | Perinatology & Neonatology | Pregnancy | Tropical Medicine | Vaccines | Women | Yellow Fever | Yellow Fever Vaccination