Highlights of Novel Vaccination Strategies in Allergen Immunotherapy.

Highlights of Novel Vaccination Strategies in Allergen Immunotherapy.
Immunol Allergy Clin North Am. 2020 Feb;40(1):15-24
Authors: Komlósi ZI, Kovács N, Sokolowska M, van de Veen W, Akdis M, Akdis CA
Abstract
Increasing safety while maintaining or even augmenting efficiency are the main goals of research for novel vaccine development and improvement of treatment schemes in allergen immunotherapy (AIT). To increase the efficacy of AIT, allergens have been coupled to innate immunostimulatory substances and new adjuvants have been introduced. Allergens have been modified to increase their uptake and presentation. Hypoallergenic molecules have been developed to improve the safety profile of the vaccines. Administration of recombinant IgG4 antibodies is a new, quick, passive immunization strategy with remarkable efficiency. Results of some current investigations aiming at further improvement of AIT vaccines have been summarized.
PMID: 31761116 [PubMed - in process]

Source: The Medical Clinics of North America - November 27, 2019 Category: General Medicine Authors: Komlósi ZI, Kovács N, Sokolowska M, van de Veen W, Akdis M, Akdis CA Tags: Immunol Allergy Clin North Am Source Type: research