High glucose concentrations mask cellular phenotypes in a stem cell model of tuberous sclerosis complex.

This article is part of the Special Issue "Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures". PMID: 31761686 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research

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Source: Nutritional Neuroscience - Category: Nutrition Authors: Source Type: research
In conclusion, PLGA NPs can efficiently carry their payloads to glioma tissue and the combined use of anticancer and anti-inflammatory drugs may exert additional anti-tumor activity.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
ConclusionAutomatic quantification of myoclonic jerks using human pose and body movement analysis of patients’ videos is feasible and was found to be quite consistent with the accepted clinical gold standard quantification method. Based on the results of this study, the automatic analytical method should be further developed and validated to improve myoclonus severity follow-up for EPM1 patients.
Source: Seizure - Category: Neurology Source Type: research
Publication date: Available online 24 January 2020Source: SeizureAuthor(s): Hui-Hsien Pan, Tung-Wei Hung, Jeng-Dau Tsai, Hsuan-Ju Chen, Pei-Fen Liao, Ji-Nan SheuABSTRACTPurposeLittle is known about whether allergic disease is associated with a subsequent increased risk of childhood-onset epilepsy. We used a large, population-based cohort study to examine whether children with antecedent allergic rhinitis (AR) were associated with a subsequent increased risk of epilepsy.MethodsThis retrospective population-based cohort study was conducted by using data from the 2000–2012 Taiwan’s National Health Insurance Resear...
Source: Seizure - Category: Neurology Source Type: research
ConclusionFrom the available evidence, FS meets more of the criteria proposed for an acceptable label than other popular terms in the field. While the term FS is neutral with regard to etiology and pathology (particularly regarding whether psychological or not), other terms such as “dissociative”, “conversion”, or “psychogenic” seizures are not. In addition, FS can potentially facilitate multidisciplinary (physical and psychological) management more than other terms. Adopting a universally accepted terminology to describe this disorder could standardize our approach to the illness and fa...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This study found that 41% of respondents reported suboptimal adherence to AED therapy, while 28.5% of respondents self-reported that they unintentionally do not take their AED medication on an occasional, regular, or frequent basis. A 5.9% of respondents self-reported that they intentionally do not take their medication as prescribed. A 6% of respondents self-reported that they are both unintentionally and intentionally nonadherent to their AED therapy. No significant associations were demonstrated between age, sex, perceived effectiveness of medication, feelings of stigma/embarrassment, adverse effects or additional neuro...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionThis is the first study to assess attitudes and practices of pediatric neurologists and epileptologists regarding sexual and reproductive healthcare for adolescent and young adult WWE. Our findings suggest that there is a need for development of improved systems for sexual and reproductive healthcare delivery and comanagement for adolescent and young adult WWE. Providers identified many barriers and facilitators that might serve as the basis for interventions to improve care.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: March 2020Source: Epilepsy &Behavior, Volume 104, Part AAuthor(s): Delphine Coste-Zeitoun, Mathieu Kuchenbuch, Daniela Pennaroli, Clémence Castaignède, Sylvia Napuri, Christine Satre, Jean-Luc Schaff, Sylvie Sukno, Marie Hélias, Nathalie de Grissac-Moriez, Georges Delattolas, Dominique Olive, Christine Bulteau, Guy Zeitoun, Anna KaminskaAbstractIntroductionThe reason why some children and adolescent with epilepsy (CAWE) still challenge the “inclusive” educative policy needs to be explored.Methods/patientsWe conducted a transversal study in French medical, social, and e...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This article is part of the Special Issue “Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures".
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Conclusions: L-1-[18F]FETrp showed clear retention in medulloblastoma tumors of Smo-Smo mice. Our preliminary medulloblastoma tumor tissue analysis indicates high expression of TDO2 enzyme, which suggests the tracer uptake reflects TDO2-mediated KP. These preclinical studies suggest that TDO2 may be a therapeutic target for medulloblastoma and L-1-[18F]FETrp has potential for PET imaging of medulloblastoma.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Radiolabeled Small Molecules and New Applications - Oncology Source Type: research
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