Startup developing AI for TB detection; secures federal business innovation grant

(Christine Coolick Creative Services, LLC) Diascopic LLC, a Cleveland-based medical research company that develops rapid, mobile, low-cost and accurate diagnostic technology, will use a highly competitive federal grant to develop and apply new artificial intelligence and digital pathology tools for detecting tuberculosis. The company has conducted preliminary studies in African clinical locations where TB is prevalent. Preliminary results were promising enough to secure $225,000 in Small Business Innovation Research funding from the NIH's National Institute for Biomedical Imaging and Bioengineering.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Abstract Methods: A retrospective follow-up study was conducted among clients on ART from 2012 to 2017. Data were collected using checklists. The Kaplan-Meier curve was employed to compare survival rates. The Cox proportional hazard model was applied to identify predictors of time to development of anemia. Results: A total of 490 ART patients were followed. The overall incidence of anemia was 27/100 person-years. The incidence was highest in the second year (18.7/100 PY) of starting ART when compared with the first year (13.8/100 PY) and third year (18.1/100 PY) of ART initiation. The independent predictors s...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
DISCUSSION:  The study showed a higher LTBI prevalence among returnees after assignments abroad than among medical personnel in Germany after TB contact who had been investigated in previous studies. In order to be able to detect LTBI infections acquired abroad, routine testing before and after an assignment abroad seems to be necessary. PMID: 32259872 [PubMed - as supplied by publisher]
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
CrystEngComm, 2020, Advance Article DOI: 10.1039/D0CE00440E, CommunicationKeke Zhang, Noalle Fellah, Alexander G. Shtukenberg, Xiaoyan Fu, Chunhua Hu, Michael D. Ward Two new metastable polymorphs of the tuberculosis drug isoniazid, considered monomorphic for sixty years, were discovered using melt crystallization and nanoscale confinement. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - CrystEngComm latest articles - Category: Chemistry Authors: Source Type: research
Authors: Ali S, Khan MT, Khan AS, Mohammad N, Khan MM, Ahmad S, Noor S, Jabbar A, Daire C, Hassan F Abstract Anti-tuberculosis therapy involves the combination of drugs to hamper the growth of Mycobacterium tuberculosis (MTB). The emergence of multidrug-resistant tuberculosis (MDR-TB) is a global concern. Pakistan has been ranked 5th position in terms of a high burden of MDR-TB in the world. The aim of the current study was to investigate the prevalence of drug resistance in MTB in Khyber Pakhtunkhwa. Random samples were collected from 25 districts using the simple random sampling formula. All samples were processe...
Source: Polish Journal of Microbiology - Category: Microbiology Tags: Pol J Microbiol Source Type: research
Authors: Goga A, Feucht U, Zar HJ, Vanker A, Wiysonge CS, McKerrow N, Wright CY, Loveday M, Odendaal W, Ramokolo V, Ramraj T, Bamford L, Green RJ, Pillay Y, Nannan N Abstract Although the neonatal mortality rate in South Africa (SA) has remained stagnant at 12 deaths per 1 000 live births, the infant and under-5 mortality rates have significantly declined since peaking in 2003. Policy changes that have influenced this decline include policies to prevent vertical HIV transmission, earlier treatment of children living with HIV, expanded immunisation policies, strengthening breastfeeding practices, and health policies...
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
Authors: Goga A, Slogrove A, Wedderburn CJ, Feucht U, Wessels J, Ramokolo V, Bhana A, Du Plessis N, Green RJ, Pillay Y, Sherman G Abstract Over the past three decades, tremendous global progress in preventing and treating paediatric HIV infection has been achieved. This paper highlights the emerging health challenges of HIV-exposed uninfected (HEU) children and the ageing population of children living with HIV (CLHIV), summarises programmatic opportunities for care, and highlights currently conducted research and remaining research priorities in high HIV-prevalence settings such as South Africa. Emerging health cha...
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
Authors: Warren R, Ismail N, Chegou NN, Theron G, Walzl G, Malherbe ST, Kinnear CJ, Van der Spuy GD, Goosen W, Miller MA, Diacon AH, Van Helden PD Abstract The South African Medical Research Council Centre for Tuberculosis Research has a rich history of high-impact research that has influenced our understating of this hyper-epidemic which is further exacerbated by the emergence and spread of drug-resistant forms of the disease. This review aims to summarise the past 30 years of research conducted in the Centre which has influenced the way that tuberculosis (TB) is diagnosed and treated. The review includes the deve...
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
Conclusion. The SAMRC has contributed substantially to the growing field of alcohol research in SA, but gaps in areas such as alcohol policy evaluation, alcohol and its association with TB and cancer, and interventional research, are evident. PMID: 32252865 [PubMed - in process]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
Authors: Mathews C, Goga A, Loveday M, Zembe W, Daviaud E, Siegfried N, Lewin S Abstract Health policy and systems research (HPSR) guides health system reforms and is essential for South Africa (SA)'s progress towards universal coverage of high-quality healthcare. For HPSR evidence to inform and strengthen health systems, it needs to flow efficiently between evidence producers, evidence synthesisers, evidence processers and disseminators and evidence implementors in an evidence ecosystem. A substantial body of evidence for health systems strengthening is generated in SA, and this informs national and international ...
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
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