The impact of particulate matter (PM2.5) on skin barrier revealed by transcriptome analysis: focusing on cholesterol metabolism

This study shows that PM2.5 may cause barrier disorders by increasing cholesterol synthesis, leading to transient accumulation of epidermal cholesterol and decrease of squalene. It was suggested that cholesterol and squalene, which are the key substances affecting skin barrier function, can be used as new biomarkers of skin damage induced by PM2.5. Moreover, it was demonstrated that GTE can reduce damage caused by PM2.5 exposure by not only anti-inflammatory and antioxidant mechanisms, but also by off-setting the disturbance to epidermal lipid homeostasis. This study demonstrates the strong potential of GTE as an active ingredient to be utilized in cosmetic products to effectively reduce the damage PM2.5 induces in skin.
Source: Toxicology Reports - Category: Toxicology Source Type: research