Choroidal metastases as initial manifestation of a papillary thyroid carcinoma: A case report.

Choroidal metastases as initial manifestation of a papillary thyroid carcinoma: A case report. Arch Soc Esp Oftalmol. 2019 Nov 20;: Authors: Chacón González M, Ibáñez Muñoz A, Rodríguez Vicente L, Ortega Renedo I, Rozanova Klecheva M, Yagüe Hernando A, Lizuaín Abadia ME, Jiménez Del Rio B Abstract The case is presented of 78 year-old who consulted due to decreased visual acuity in right eye for several months. Indirect ophthalmoscopy revealed an orange-yellow coloured choroidal mass at the posterior pole, without retinal detachment. Computed tomography showed a thyroid mass in the isthmus, as well as multiple pulmonary nodules and metastatic foci. The findings of transbronchial lung biopsy were compatible with metastatic dissemination. Fine-needle aspiration biopsy of thyroid nodule was diagnostic for a with columnar cell variant of papillary thyroid cancer. Positron emission tomography confirmed papillary thyroid carcinoma. The patient underwent total thyroidectomy and radioactive iodine therapy. PMID: 31759732 [PubMed - as supplied by publisher]
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research

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Source: Life Sciences - Category: Biology Source Type: research
CONCLUSIONS: The rare frameshift mutation in the TINF2 gene and the associated longer telomere length suggest that dysregulated telomeres could be a mechanism predisposing to PTC and melanoma. DNA coding variants in shelterin genes are rare. Further studies are required to evaluate the roles of variants in shelterin genes in thyroid cancer and melanoma. PMID: 31928178 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Papillary thyroid carcinomas (PTC) account for 90% of human thyroid cancer cases which represent 1% of all cancer cases. They are likely to develop from papillary thyroid microcarcinomas (PTMC) found in up to 36% of healthy individuals due to rare progression events (0.01%). Although the prognosis of PTCs is excellent, 5% to 10% of tumors display an unfavorable outcome. About 45% of PTCs exhibit activating BRAFV600E mutations. Rats of the inbred BD strains postnatally exposed to the carcinogen N-ethyl-N-nitrosourea developed PTMCs which closely resembled their human counterparts judging from their histology, size, and marg...
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research
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Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Publication date: Available online 9 January 2020Source: European Journal of Surgical OncologyAuthor(s): I.J. Nixon, J.P. Shah, M. Zafereo, R.S. Simo, I.D. Hay, C. Suárez, P. Zbären, A. Rinaldo, A. Sanabria, C. Silver, A. Mäkitie, V. Vander Poorten, L.P. Kowalski, A.R. Shaha, G.W. Randolph, A. FerlitoAbstractWith improved understanding of the biology of differentiated thyroid carcinoma its management is evolving. The approach to surgery for the primary tumour and elective nodal surgery is moving from a “one size -fits-all” recommendation to a more personalised approach based on risk group strat...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
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Source: Experimental and Molecular Pathology - Category: Pathology Authors: Tags: Exp Mol Pathol Source Type: research
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Source: Pathology Research and Practice - Category: Pathology Source Type: research
CONCLUSIONS: The differential diagnosis between OM and primary ovarian cancer can be challenging for the pathologist as well and immunostaining is of help. GCFDP15 is the most specific for breast carcinoma. In contrast with the recent papers published in the literature, we detected TTF-1 cytoplasmic expression in invasive breast carcinoma by SPT24 clone. PMID: 31912104 [PubMed - in process]
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Our systematic review of the literature aimed to confirm the controversial association between preoperative TSH levels and the risk of DTC in patients who present with thyroid nodules. We extracted and assessed data from 10 key publications that previously investigated papillary thyroid carcinomas to predict the risk of malignancy. The risk of bias was checked and based on our assessment, a higher preoperative increase in TSH levels should be incorporated into the diagnostic algorithm for DTC..
Source: American Journal of Surgery - Category: Surgery Authors: Source Type: research
Authors: Zhang M, Tufano RP, Russell J, Zhang Y, Zhang Y, Qiao Z, Luo Y Abstract BACKGROUND: Papillary thyroid micro-carcinoma (PTMC) typically carries an excellent prognosis regardless of the treatment option pursued. Radiofrequency ablation (RFA) for thyroid disease has been utilized for benign lesions and in patients who are poor surgical candidates for thyroid cancers with compression symptoms, but the efficacy and limitations of RFA as first line therapy for PTMC has not been described in adequate detail. The purpose of our study was to investigate RFA versus thyroidectomy in terms of efficacy, oncologic outco...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
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