Linkage between evolution of pregnancy and cancer spread explained

In humans, the placenta invades the wall of the uterus in much the same way that cancer cells invade the surrounding tissues at the outset of metastasis.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news

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This study has demonstrated higher PLAC1 levels in infertile women with RIF and RPL for the first time; suggesting that it could have a negative effect on implantation in these populations. PLAC1 could be detected in the serum as a biomarker that is associated with RIF and RPL. What are the implications of these findings for clinical practice and/or further research? Defining the precise role of PLAC1 during implantation will provide new insight into understanding of poor reproductive outcomes such as RIF and RPL and help in developing treatment strategies. Further large-scale studies with more patients are needed to uncov...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
CONCLUSIONS: The present study indicates that low SES is a major risk factor associated with cervical cancer. Bringing awareness about HPV infection and intensifying routine screening programs for cervical cancer will help reduce the risk of cervical cancer among women with low SES in this region. PMID: 31759367 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Purpose of review To investigate the JZE alterations in gynecological and obstetrical disorders and impact on diagnosis, prognosis and treatment. Recent findings JZE was found to be significantly extended in patients with endometriosis, leading to the conclusion that endometriosis is a primary disease of the uterus, much like adenomyosis. Statistical correlation was then demonstrated between the severity of endometriosis and the depth of the adenomyosis infiltrates, hence the thickening of the JZE. Stem cells, predominantly found in the JZE were also found in histological sections of leiomyoma, suggested to be the ori...
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: WOMEN'S HEALTH: Edited by Joseph Aquilina Source Type: research
Authors: Elias KM, Berkowitz RS, Horowitz NS Abstract Gestational trophoblastic disease refers to a series of interrelated tumors arising from the placenta, including benign molar pregnancies as well as the malignant conditions termed gestational trophoblastic neoplasia (GTN). GTN most commonly follows a molar pregnancy but may develop after any gestation. The wide availability of first trimester ultrasound and serum human chorionic gonadotropin (hCG) measurement has changed the presentation of molar pregnancy in recent decades from a second trimester to a first trimester disease, such that most patients have few s...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
BOSTON (CBS) – Not only do IUDs prevent pregnancy, they may lower the risk of ovarian cancer in the women who use them. Researchers at the University of Colorado reviewed a dozen prior studies involving several thousand patients and found that women who used IUDs were up to 32-percent less likely than other women to develop ovarian cancer. It’s not clear why, but scientists found that the hormones released by some IUDs may block estrogen which help ovarian tumor glow. And having a foreign body in the uterus may trigger the immune system to help fight cancer. Birth control pills have also been linked to a lower ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Healthwatch News Syndicated CBSN Boston Syndicated Local Dr. Mallika Marshall IUD ovarian cancer Source Type: news
Contributors : Leah McNally ; Yan Zhou ; Joshua F Robinson ; Guangfeng Zhao ; Lee-May Chen ; Hao Chen ; M Y Kim ; Mirhan Kapidzic ; Matthew Gormley ; Susan J FisherSeries Type : Expression profiling by arrayOrganism : Homo sapiensIn humans, a subset of placental cytotrophoblasts (CTBs) invades the uterus and its vasculature, anchoring the pregnancy and ensuring adequate blood flow to the fetus. Appropriate depth is critical. Shallow invasion increases the risk of pregnancy complications, e.g., severe preeclampsia. Overly deep invasion, the hallmark of placenta accreta spectrum (PAS), increases the risk of pre-term delivery...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Quality of life transplantations (e.g. hand, face, etc.), in contrast to life-saving transplantations (e.g. heart, lungs, etc.), have become increasingly popular and have gained more acceptance in the medical and lay communities. In the last two decades transplants for sexual and reproductive organs—specifically allogenic transplantations of the uterus, ovary, and penis—have emerged as yet another type of quality of life transplants. The purpose of uterus transplantations is to allow cisgender women with absolute uterine factor infertility to experience pregnancy. Although the first uterus transplantation took ...
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care assisted reproduction feminist ethics reproductive medicine Sex and Sexuality surgical ethics syndicated transplantation Women's Reproductive Rights Source Type: blogs
In this study, we aimed to identify and determine the efficacy of serum biomarkers for the prompt diagnosis of ectopic pregnancy. For this purpose, the serum concentrations of progesterone, β human chorionic gonadotropin (β‑hCG) and cancer antigen‑125 (CA125) were detected by solid‑phase, competitive binding chemiluminescent enzyme immunoassays. Flow cytometry was used to analyze the percentage of CD3+ T cells in women with ectopic pregnancy. Pathological analysis of tubal and villus tissues was performed by hematoxylin and eosin (H&E) staining. After receiving an injection of methotrexate (MTX), patie...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Abstract Stanniocalcin-1 (STC-1) is a pro-survival factor that protects tissues against stressors, such as hypoxia and inflammation. STC-1 is co-expressed with the endometrial receptivity markers, and recently endometrial STC-1 was reported to be dysregulated in endometriosis, a condition linked with endometrial progesterone resistance and inflammation. These features are also common in the endometrium in women with polycystic ovary syndrome (PCOS), the most common endocrine disorder in women. Given that women with PCOS present with subfertility, pregnancy complications, and increased risk for endometrial cancer, ...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
A 31-year-old pregnant female who was at 16 weeks gestational age presented to the emergency room with severe right sided flank pain and low-grade fevers. She denied hematuria or dysuria. She had a mother with endometrial cancer and no family history of renal malignancy or congenital anomalies. Her physical exam was notable for a large and tender right upper quadrant mass and a gravid uterus. The rest of her exam was unremarkable as were her basic chemistries and blood counts. Urinalysis was positive for nitrites and leukocyte esterase, and urine culture grew>100,000 colonies of E.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
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